1. Anti-infection
  2. Antibiotic
  3. Bleomycin

Bleomycin is a glycopeptide antibiotic. Bleomycin has potent antitumour activities against a range of lymphomas, head and neck cancers and germ-cell tumours. Bleomycin can be used for the research of cancer and chemotherapy.

The free form of the compound is prone to instability, it is advisable to consider the stable salt form (Bleomycin sulfate) that retains the same biological activity.

For research use only. We do not sell to patients.

Bleomycin Chemical Structure

Bleomycin Chemical Structure

CAS No. : 11056-06-7

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Description

Bleomycin is a glycopeptide antibiotic. Bleomycin has potent antitumour activities against a range of lymphomas, head and neck cancers and germ-cell tumours. Bleomycin can be used for the research of cancer and chemotherapy[1][2][3][4].

IC50 & Target

Glycopeptide

 

In Vitro

Bleomycin (0-4 mU/mL; 1 h) induces double-strand break in V79 cells[2].
Bleomycin (0-1 mU/mL; 1 h) reduces migration of DNA from S-phase cells[2].
Bleomycin (0-3 μg/mL; 1 h) induces chromatid aberrations in G2 cells[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Bleomycin (1 mg and 10 μg; retro-orbitary sinus injection once) affects cells in mitosis, induces apoptosis in tumor models[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57Bl/6 mice with LPB and B16F0 tumours[4]
Dosage: 1 mg and 10 μg
Administration: Retro-orbitary sinus injection; 1 mg and 10 μg once
Result: Decreased in the fraction of cells in mitosis in both tumours, induced cell apoptosis after the electric pulses delivery, inceased the amount of atypical cells in LPB tumours.
Clinical Trial
CAS No.
SMILES

O=C(C1=NC([C@H](CC(N)=O)NC[C@H](N)C(N)=O)=NC(N)=C1C)N[C@H](C(N[C@H](C)[C@@H](O)[C@H](C)C(N[C@]([C@H](O)C)([H])C(NCCC2=NC(C3=NC(C(N[R])=O)=CS3)=CS2)=O)=O)=O)[C@H](C4=CN=CN4)O[C@H]5[C@H]([C@H]([C@@H]([C@@H](O5)CO)O)O)O[C@]6([H])[C@H]([C@H]([C@@H]([C@H](O6)CO)O)OC(N)=O)O.NC(NCCCC[R])=N.[R]CCC[S+](C)C.[R=].[Bleomycin A2].[R=].[Bleomycin B2]

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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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Bleomycin Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Bleomycin
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HY-108345
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