1. Cell Cycle/DNA Damage
    Anti-infection
  2. DNA/RNA Synthesis
    Antibiotic
  3. Bleomycin sulfate

Bleomycin sulfate 

Cat. No.: HY-17565 Purity: 99.49%
Handling Instructions

Bleomycin sulfate is a DNA synthesis inhibitor. Bleomycin hydrochloride is a DNA damaging agent. Bleomycin sulfate is an antitumor antibiotic.

For research use only. We do not sell to patients.

Bleomycin sulfate Chemical Structure

Bleomycin sulfate Chemical Structure

CAS No. : 9041-93-4

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10 mg USD 168 In-stock
Estimated Time of Arrival: December 31
50 mg USD 672 In-stock
Estimated Time of Arrival: December 31
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Customer Review

Based on 11 publication(s) in Google Scholar

Other Forms of Bleomycin sulfate:

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Description

Bleomycin sulfate is a DNA synthesis inhibitor. Bleomycin hydrochloride is a DNA damaging agent. Bleomycin sulfate is an antitumor antibiotic[1].

IC50 & Target

DNA/RNA Synthesis[1]

In Vitro

Bleomycin (BLM) is chosen as the best-studied micronucleus (MN) inducers in human lymphocytes with different mechanisms of genotoxicity. The most frequent Bleomycin-induced DNA lesions are single and double strand breaks and single apuinic/apyrimidinic sites. At the same time Bleomycin is true radiomimetic compound, resembling almost completely the genetic effect of ionizing radiation[1]. The IC50 value of Bleomycin sulfate for UT-SCC-19A cell line is 4.0±1.3 nM. UT-SCC-12A and UT-SCC-12B are both more resistant to Bleomycin (BLM); IC50 values are 14.2±2.8 nM and 13.0±1.1 nM, respectively[2].

In Vivo

Bleomycin sulfate treatment (3.5-4.0 mg/kg; intra-tracheal) on day 0, body weights decreases by day 4 then increases by Day 7 through the end of the study[3].
Bleomycin sulfate (3.5-4.0 mg/kg; intra-tracheal) produces a statistically significant increase in lung hydroxyproline levels, and also increases right caudal lung lobe mass[3].

Animal Model: Male Fischer 344 rats, 8-10 week old, weighing 150-250 g[3]
Dosage: 3.5-4 mg/kg
Administration: Intra-tracheal
Result: Body weights decreased by day 4 then increased by Day 7 through the end of the study.
Clinical Trial
Molecular Weight

1512.62

Formula

C₅₅H₈₅N₁₇O₂₅S₄

CAS No.

9041-93-4

SMILES

NC(C[[email protected]](NC[[email protected]@H](N)C(N)=O)C1=NC(N)=C(C)C(C(N[[email protected]](C(N[[email protected]@H](C)[[email protected]@H]([[email protected]@H](C)C(N[[email protected]@H](C(NCCC2=NC(C3=NC(C(NCCC[S+](C)C)=O)=CS3)=CS2)=O)[[email protected]](O)C)=O)O)=O)C(C4=CNC=N4)O[[email protected]@H]5[[email protected]]([H])(O[[email protected]@H]6[[email protected]@H](O)[[email protected]@H](OC(N)=O)[[email protected]](O)[[email protected]@H](CO)O6)[[email protected]](O)[[email protected]@H](O)[[email protected]@H](CO)O5)=O)=N1)=O.[O-]S(=O)(O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : 255 mg/mL (168.58 mM; Need ultrasonic and warming)

DMSO : 16.67 mg/mL (11.02 mM; Need ultrasonic)

DMF : < 1 mg/mL (insoluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.6611 mL 3.3055 mL 6.6110 mL
5 mM 0.1322 mL 0.6611 mL 1.3222 mL
10 mM 0.0661 mL 0.3306 mL 0.6611 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (1.38 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (1.38 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (1.38 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: 99.49%

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Keywords:

BleomycinDNA/RNA SynthesisAntibioticInhibitorinhibitorinhibit

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Bleomycin sulfate
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