1. Protein Tyrosine Kinase/RTK
  2. c-Kit

Sitravatinib (Synonyms: MGCD516; MG516)

Cat. No.: HY-16961 Purity: 98.64%
Handling Instructions

Sitravatinib is a novel small molecule inhibitor targeting multiple RTKs involved in driving sarcoma cell growth with IC50 of 3980 nmol/L

For research use only. We do not sell to patients.

Sitravatinib Chemical Structure

Sitravatinib Chemical Structure

CAS No. : 1123837-84-2

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 111 In-stock
Estimated Time of Arrival: December 31
5 mg USD 80 In-stock
Estimated Time of Arrival: December 31
10 mg USD 120 In-stock
Estimated Time of Arrival: December 31
50 mg USD 300 In-stock
Estimated Time of Arrival: December 31
100 mg USD 490 In-stock
Estimated Time of Arrival: December 31
200 mg USD 820 In-stock
Estimated Time of Arrival: December 31
500 mg   Get quote  
1 g   Get quote  

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Customer Review

  • Biological Activity

  • Technical Information

  • Purity & Documentation

  • References

Description

Sitravatinib is a novel small molecule inhibitor targeting multiple RTKs involved in driving sarcoma cell growth with IC50 of 3980 nmol/L in vitro: MGCD516 is superior to other multi-kinase inhibitors in inhibiting cell proliferation, RTK phosphorylation, and phosphorylation of downstream effectors. MGCD516 is unique in a way that it has broad spectrum activity against many RTKs including c-Met, c-Kit, Axl, PDGFR, and Eph receptors that are known to play a role in driving sarcoma cell growth In vivo: MGCD516 induces significant tumor growth suppression than imatinib and crizotinib.

Clinical Trial
Solvent & Solubility
In Vitro: 

DMSO : ≥ 32 mg/mL (50.82 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.5881 mL 7.9405 mL 15.8811 mL
5 mM 0.3176 mL 1.5881 mL 3.1762 mL
10 mM 0.1588 mL 0.7941 mL 1.5881 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

629.68

Formula

C₃₃H₂₉F₂N₅O₄S

CAS No.

1123837-84-2

SMILES

O=C(C1(C(NC2=CC=C(F)C=C2)=O)CC1)NC3=CC=C(OC4=C5C(C=C(C6=NC=C(CNCCOC)C=C6)S5)=NC=C4)C(F)=C3

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

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This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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Product Name:
Sitravatinib
Cat. No.:
HY-16961
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Sitravatinib

Cat. No.: HY-16961