DDR2 - discoidin domain receptor tyrosine kinase 2 Gene

Also Known as TKT; WRCN; MIG20a; NTRKR3; TYRO10

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 4921

About DDR2

Cytogenetic location: 1q23.3 Genomic coordinates (GRCh38): 1:162,630,863-162,787,405 (from NCBI)

This gene has 9 transcripts (splice variants), 263 orthologues, 53 paralogues and is associated with 106 phenotypes. Broad expression in fat (RPKM 30.2), adrenal (RPKM 24.5) and 20 other tissues.

Summary

This gene encodes a member of the Discoidin Domain Receptor subclass of the receptor tyrosine kinase (RTKs) protein family. RTKs play a key role in the communication of cells with their microenvironment. The encoded protein is a collagen-induced receptor that activates signal transduction pathways involved in cell adhesion, proliferation, and extracellular matrix remodeling. This protein is expressed in numerous cell types and may alos be involved in wound repair and regulate tumor growth and invasiveness. Mutations in this gene are the cause of short limb-hand type spondylometaepiphyseal dysplasia. [provided by RefSeq, Aug 2017]

DDR2 Products (8)

mRNA	Protein	Name
NM_001354983.2	NP_001341912.1	discoidin domain-containing receptor 2 precursor
NM_001014796.3	NP_001014796.1	discoidin domain-containing receptor 2 precursor
NM_001354982.2	NP_001341911.1	discoidin domain-containing receptor 2 precursor
XM_011509587.3	XP_011507889.1	discoidin domain-containing receptor 2 isoform X1
XM_047421554.1	XP_047277510.1	discoidin domain-containing receptor 2 isoform X1
XM_047421565.1	XP_047277521.1	discoidin domain-containing receptor 2 isoform X2
XM_011509588.4	XP_011507890.1	discoidin domain-containing receptor 2 isoform X3
NM_006182.4	NP_006173.2	discoidin domain-containing receptor 2 precursor

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables collagen binding	IDA IDA: Inferred from direct assay	20004161	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	17703188	GOA
enables protein tyrosine kinase collagen receptor activity	IDA IDA: Inferred from direct assay	9659899	GOA
enables transmembrane receptor protein tyrosine kinase activity	IDA IDA: Inferred from direct assay	20004161	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in collagen-activated tyrosine kinase receptor signaling pathway	IDA IDA: Inferred from direct assay	16186108	GOA
involved in peptidyl-tyrosine phosphorylation	IDA IDA: Inferred from direct assay	20004161	GOA
involved in positive regulation of DNA-binding transcription factor activity	IMP IMP: Inferred from mutant phenotype	20564243	GOA
involved in positive regulation of osteoblast differentiation	IMP IMP: Inferred from mutant phenotype	20564243	GOA
involved in positive regulation of protein kinase activity	IMP IMP: Inferred from mutant phenotype	20564243	GOA
involved in protein autophosphorylation	IDA IDA: Inferred from direct assay	16186108	GOA
involved in regulation of bone mineralization	IMP IMP: Inferred from mutant phenotype	20564243	GOA
involved in regulation of tissue remodeling	IMP IMP: Inferred from mutant phenotype	30449416	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DDR2 Protein Structure

F5_F8_type_C

Pkinase_Tyr

0
200
400
600
800
855 a.a.

Protein Preferred Names	Protein Names
discoidin domain-containing receptor 2	CD167 antigen-like family member B cell migration-inducing protein 20 discoidin domain receptor 2 discoidin domain receptor family, member 2 discoidin domain-containing receptor tyrosine kinase 2 hydroxyaryl-protein kinase migration-inducing gene 16 protein neurotrophic tyrosine kinase receptor related 3 receptor protein-tyrosine kinase TKT tyrosine-protein kinase TYRO10

DDR2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	DDR2	Q16832	COL11A2	Homo sapiens	P13942	NMR	17703188
Intra	DDR2	Q16832	CDC37	Homo sapiens	Q16543	Affinity Chrom	35384245
Intra	DDR2	Q16832	CDC37	Homo sapiens	Q16543	Lumier	25036637
Intra	DDR2	Q16832	CDC37	Homo sapiens	Q16543	BioID	35384245
Intra	DDR2	Q16832	HSP90AB1	Homo sapiens	P08238	Lumier	22939624
Intra	DDR2	Q16832	HSP90AB1	Homo sapiens	P08238	Affinity Chrom	35384245
Intra	DDR2	Q16832	HSP90AB1	Homo sapiens	P08238	Anti Tag CoIP	22939624
Intra	DDR2	Q16832	NTRK3	Homo sapiens	Q16288	Anti Tag CoIP	35384245
Intra	DDR2	Q16832	NTRK3	Homo sapiens	Q16288	Affinity Chrom	35384245
Intra	DDR2	Q16832	DDR1	Homo sapiens	Q08345	Affinity Chrom	35384245
Intra	DDR2	Q16832	DDR1	Homo sapiens	Q08345	Anti Tag CoIP	35384245

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant DDR2 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P76867	DDR2 Protein, Human (Active, sf9, His-GST)	Q16832 (R422-E855)	≥ 90%, as determined by reducing SDS-PAGE.
HY-P76868	DDR2 Protein, Human (HEK293, Fc)	Q16832/NP_001014796.1 (K22-R399)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P76869	DDR2 Protein, Human (HEK293, His)	Q16832/NP_001014796.1 (K22-R399)	≥ 95%, as determined by reducing SDS-PAGE.

DDR2 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P83622	DDR2 Antibody (YA3367)	WB	Human, Mouse, Rat
HY-P84622	DDR2 Antibody (YA4319)	IHC-P, ICC/IF, FC, ELISA	Human, Mouse, Rat, Rabbit
HY-P84622A	DDR2 Antibody (YA4319)(PBS only)	IHC-P, ICC/IF, FC, ELISA	Human, Mouse, Rat, Rabbit
HY-P85120	DDR2 Antibody (YA4812)	WB, IHC-P, ICC/IF, ELISA	Human

Related Diseases

Diseases	Alias
Pectus Excavatum	Funnel Chest Congenital Pectus Excavatum
Osteoarthritis	Osteoarthrosis Degenerative Joint Disease Hypertrophic Arthritis Arthropathy Degenerative Polyarthritis Degenerative Arthritis Osteoarthrosis And Allied Disorder Arthritis, Degenerative Oa Osteoarthritis Deformans Osteoarthrosis Deformans Kashin-Beck Disease
Warburg-Cinotti Syndrome	WRCN
Bone Disease	Bone Diseases Skeletal Disease Skeletal Disorder Disorder Of Skeletal System
Adenosquamous Lung Carcinoma
Lung Adenoid Cystic Carcinoma	Adenoid Cystic Carcinoma Of Lung Pulmonary Adenoid Cystic Carcinoma
Brachydactyly
Spondyloepimetaphyseal Dysplasia	Dysplasia, Spondyloepimetaphyseal
Spondyloepiphyseal Dysplasia Congenita	SEDC Sed Congenita Spondyloepiphyseal Dysplasia, Congenital Type Late Spondyloepiphyseal Dysplasia Sed, Congenital Type Congenital Spondyloepiphyseal Dysplasia Spranger-Wiedemann Disease Spondyloepiphyseal Dysplasia Congenital Type Dysplasia, Spondyloepiphyseal, Congenita Spondyloepiphyseal Dysplasia, Congenita Spondyloepiphyseal Dysplasia Tarda, X-Linked
Corneal Neovascularization	Corneal Neovascularisation Corneal Vascularisation Extensive Superficial Corneal Vascularisation
Spondylometaepiphyseal Dysplasia, Short Limb-Hand Type	Spondyloepimetaphyseal Dysplasia-Short Limb-Abnormal Calcification Syndrome Smed-Sl Smed-Sl/Ac Smed Short Limb-Abnormal Calcification Type Smed Short Limb-Hand Type Spondylometaepiphyseal Dysplasia Short Limb-Hand Type Smed, Type Ii Smed Type 2 Spondylometaepiphyseal Dysplasia Short Limb-Abnormal Calcification Type Smed, Short Limb-Hand Type Spondylometaepiphyseal Dysplasia, Short Limb-Abnormal Calcification Type Smed, Short Limb-Abnormal Calcification Type Spondyloepimetaphyseal Dysplasia - Short Limb - Abnormal Calcification Spondyloepimetaphyseal Dysplasia, Short Limb-Hand Type SEMD-SL Smed Type Ii Dysplasia, Spondylometaepiphyseal, Short Limb-Hand Type
Squamous Cell Carcinoma	Epidermoid Carcinoma Squamous Cell Cancer Carcinoma, Squamous Cell Malignant Squamous Cell Tumor Squamous Carcinoma Squamous Cell Epithelioma Squamous Cell Skin Cancer Carcinoma Squamous Cell Neoplasms, Squamous Cell Squamous Cell Carcinoma - Category Malignant Squamous Cell Neoplasm Squamous Cell Carcinoma Of Skin
Keloid Formation
Breast Cancer	Breast Carcinoma Breast Cancer, Familial Malignant Neoplasm Of Breast Male Breast Cancer Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation
Lung Squamous Cell Carcinoma	Squamous Cell Carcinoma Of Lung Squamous Cell Lung Carcinoma Epidermoid Cell Carcinoma Of The Lung Squamous Cell Lung Cancer
Lung Cancer	Lung Carcinoma Non-Small Cell Lung Carcinoma Lung Cancer, Protection Against Lung Cancer, Susceptibility To Adenocarcinoma Of Lung, Somatic Nonsmall Cell Lung Cancer Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In Lung Neoplasm Carcinoma Of Lung Lung Non-Small Cell Carcinoma Non-Small Cell Lung Cancer Nsclc Lung Neoplasms Malignant Neoplasm Of Lung Alveolar Cell Carcinoma Nonsmall Cell Lung Cancer, Somatic Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer, Susceptibility To Lung Cancer, Somatic Lung Cancer, Resistance To Cancer Of Lung Cancer Of Bronchus Cancer Of The Lung Lung Malignancies Lung Malignant Tumors Malignant Lung Tumor Malignant Tumor Of Lung Pulmonary Cancer Pulmonary Carcinoma Pulmonary Neoplasms Respiratory Carcinoma LNCR Adenocarcinoma Of Lung Neoplasm Of Lung Cancer Lung Carcinoma Non-Small Cell Lung Carcinoma, Non-Small-Cell Lung Lung Cancers Lung Carcinomas Cancer, Lung Cancer, Lung, Non-Small Cell Primary Malignant Neoplasm Of Lung Bronchioloalveolar Adenocarcinoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-16961	Sitravatinib	Inhibitor	99.57%	Phase 3

Pre-clinical Phase

Bioactive Molecules (15)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-114169	WRG-28	Inhibitor	99.76%	Unkown
HY-135401	VU6015929	Inhibitor	99.50%	Unkown
HY-114173	DDR1-IN-4	Inhibitor	98.19%	Unkown
HY-NP175	Collagen (bovine skin)	Ligand	/	Unkown
HY-114311	FGFR1/DDR2 inhibitor 1	Inhibitor	98.26%	Unkown
HY-156552	DDR1/2 inhibitor-2	Inhibitor	99.73%	Unkown
HY-13979A	DDR1-IN-1 dihydrochloride	Inhibitor	98.92%	Unkown
HY-167208	SR-302	Inhibitor	98.51%	Unkown
HY-175202	CIDD-8633	Inhibitor	/	Unkown
HY-16961A	Sitravatinib malate	Inhibitor	/	Unkown
HY-176849	DDR2-IN-2	Inhibitor	/	Unkown
HY-14979A	ML786 dihydrochloride	Inhibitor	/	Unkown
HY-181839	DDR1/2 IN-4	Inhibitor	/	Unkown
HY-162102	DDR1-IN-8	Inhibitor	/	Unkown
HY-122848	DDR1/2 inhibitor-3	Inhibitor	/	Unkown

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P992066	Anti-Mouse DDR2 Antibody (DAB0065)	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	DDR2	RGD	RGD:619855
Bos taurus	DDR2	VGNC	VGNC:27953
Macaca mulatta	DDR2	VGNC	VGNC:71758
Felis catus	DDR2	VGNC	VGNC:61395
Mus musculus	DDR2	MGD	MGI:1345277
Canis familiaris	DDR2	VGNC	VGNC:39842
Others	DDR2	NCBI