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Cat. No.: HY-162102

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DDR1-IN-8

DDR1-IN-8 (compound 7s) is a potent inhibitor of DDR1/2, with the IC₅₀ values of 0.045 μM and 0.126 μM, respectively. DDR1-IN-8 has anti-tumor activity.

For research use only. We do not sell to patients.

CAS No.: 3038810-92-0
Formula: C₂₃H₂₄F₃N₅O₂
Molecular Weight:459.46

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

DDR1-IN-8 Chemical Structure

CAS No.: 3038810-92-0

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
Chemical Information
Protocols (1)
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

DDR1-IN-8 (compound 7s) is a potent inhibitor of DDR1/2, with the IC₅₀ values of 0.045 μM and 0.126 μM, respectively. DDR1-IN-8 has anti-tumor activity^[1].

IC₅₀ & Target

DDR1

DDR2

All Discoidin Domain Receptor Isoforms :

DDR1
DDR2

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	1.84 μM Compound: 7s	Antiproliferative activity against human A549 cells incubated for 72 hrs by MTT assay Antiproliferative activity against human A549 cells incubated for 72 hrs by MTT assay	[PMID: 38171149]
NCI-H1975	IC₅₀	1.87 μM Compound: 7s	Antiproliferative activity against human NCI-H1975 cells incubated for 72 hrs by MTT assay Antiproliferative activity against human NCI-H1975 cells incubated for 72 hrs by MTT assay	[PMID: 38171149]

Chemical Information

CAS No. 3038810-92-0
Molecular Weight 459.46
Formula C₂₃H₂₄F₃N₅O₂
SMILES

O=C(NCC1=CN(CC(N2CCN(CC2)C)=O)C3=C1C=C(F)C=C3)NC4=CC=C(C=C4F)F
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocols

All Cell Biology

Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Shangke Liu, et al. Design, synthesis, and biological evaluation of novel discoidin domain receptor inhibitors for the treatment of lung adenocarcinoma and pulmonary fibrosis. Eur J Med Chem. 2024 Feb 5:265:116100. [Content Brief]

Calculators

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Dilution Calculator

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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