DDR1-IN-1 dihydrochloride

Name: DDR1-IN-1 dihydrochloride
Brand: MedChemExpress
SKU: HY-13979A
Rating: 5.0 (5 reviews)

Cat. No.: HY-13979A Purity: 98.92%: Data Sheet
COA

SDS
Handling Instructions
FAQs
Technical Support

DDR1-IN-1 dihydrochloride is a potent and selective DDR1 receptor tyrosine kinase inhibitor with an IC₅₀ of 105 nM; 4-fold less potent for DDR2 (IC₅₀ = 413 nM).

For research use only. We do not sell to patients.

DDR1-IN-1 dihydrochloride Chemical Structure

CAS No. : 1780303-76-5

Size	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water ready for reconstitution	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in Water	In-stock	Estimated Time of Arrival: December 31
Solid
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
25 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	In-stock	Estimated Time of Arrival: December 31
100 mg	In-stock	Estimated Time of Arrival: December 31
200 mg	Get quote
500 mg	Get quote

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Customer Review

Based on 5 publication(s) in Google Scholar

Other Forms of DDR1-IN-1 dihydrochloride:

DDR1-IN-1 In-stock

5 Publications Citing Use of MCE DDR1-IN-1 dihydrochloride

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DDR1 DDR2

Biological Activity
Purity & Documentation
References
Customer Review

Description

DDR1-IN-1 dihydrochloride is a potent and selective DDR1 receptor tyrosine kinase inhibitor with an IC₅₀ of 105 nM; 4-fold less potent for DDR2 (IC₅₀ = 413 nM)^[1].

IC₅₀ & Target^[1]

DDR1

105 nM (IC₅₀)

DDR2

413 nM (IC₅₀)

In Vitro

DDR1-IN-1 effectively blocks collagen-induced DDR1 pY513 autophosphorylation in U2OS cells (EC₅₀ = 86.76 nM) with excellent selectivity over a panel of >380 kinases. DDR1-IN-1 inhibits DDR2-mediated MT1-MMP activation in human rheumatoid synovial fibroblasts (RASF) upon collagen stimulation (IC₅₀ < 2.5 μM) and enhances PI3K/mTOR inhibitor GSK2126458 antiproliferation efficacy in SNU-1040 colorectal cancer culture^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

625.51

Formula

C₃₀H₃₃Cl₂F₃N₄O₃

CAS No.

1780303-76-5

Appearance

Solid

Color

Light yellow to yellow

SMILES

CC1=C(C=C(C=C1)NC(C2=CC=C(C(C(F)(F)F)=C2)CN3CCN(CC3)CC)=O)OC4=CC(C5)=C(C=C4)NC5=O.Cl.Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

H₂O : 100 mg/mL (159.87 mM; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.5987 mL	7.9935 mL	15.9870 mL
5 mM	0.3197 mL	1.5987 mL	3.1974 mL
10 mM	0.1599 mL	0.7993 mL	1.5987 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 98.92%

Select Batch:

Data Sheet (272 KB) SDS (252 KB)

COA (248 KB) HNMR (388 KB) CNMR (645 KB) LCMS (95 KB)

Handling Instructions (2659 KB)

References

[1]. Kim HG, et al. Discovery of a potent and selective DDR1 receptor tyrosine kinase inhibitor. ACS Chem Biol. 2013 Oct 18;8(10):2145-50. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	1.5987 mL	7.9935 mL	15.9870 mL	39.9674 mL
	5 mM	0.3197 mL	1.5987 mL	3.1974 mL	7.9935 mL
	10 mM	0.1599 mL	0.7993 mL	1.5987 mL	3.9967 mL
	15 mM	0.1066 mL	0.5329 mL	1.0658 mL	2.6645 mL
	20 mM	0.0799 mL	0.3997 mL	0.7993 mL	1.9984 mL
	25 mM	0.0639 mL	0.3197 mL	0.6395 mL	1.5987 mL
	30 mM	0.0533 mL	0.2664 mL	0.5329 mL	1.3322 mL
	40 mM	0.0400 mL	0.1998 mL	0.3997 mL	0.9992 mL
	50 mM	0.0320 mL	0.1599 mL	0.3197 mL	0.7993 mL
	60 mM	0.0266 mL	0.1332 mL	0.2664 mL	0.6661 mL
	80 mM	0.0200 mL	0.0999 mL	0.1998 mL	0.4996 mL
	100 mM	0.0160 mL	0.0799 mL	0.1599 mL	0.3997 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.