1. Protein Tyrosine Kinase/RTK
  2. Discoidin Domain Receptor
  3. DDR1-IN-1 dihydrochloride

DDR1-IN-1 dihydrochloride 

Cat. No.: HY-13979A
Handling Instructions

DDR1-IN-1 dihydrochloride is a potent and selective DDR1 receptor tyrosine kinase inhibitor with an IC50 of 105 nM; 4-fold less potent for DDR2 (IC50 = 413 nM).

For research use only. We do not sell to patients.

DDR1-IN-1 dihydrochloride Chemical Structure

DDR1-IN-1 dihydrochloride Chemical Structure

CAS No. : 1780303-76-5

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Description

DDR1-IN-1 dihydrochloride is a potent and selective DDR1 receptor tyrosine kinase inhibitor with an IC50 of 105 nM; 4-fold less potent for DDR2 (IC50 = 413 nM)[1].

IC50 & Target[1]

DDR1

105 nM (IC50)

DDR2

413 nM (IC50)

In Vitro

DDR1-IN-1 effectively blocks collagen-induced DDR1 pY513 autophosphorylation in U2OS cells (EC50 = 86.76 nM) with excellent selectivity over a panel of >380 kinases. DDR1-IN-1 inhibits DDR2-mediated MT1-MMP activation in human rheumatoid synovial fibroblasts (RASF) upon collagen stimulation (IC50 < 2.5 μM) and enhances PI3K/mTOR inhibitor GSK2126458 antiproliferation efficacy in SNU-1040 colorectal cancer culture[1].

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
Molecular Weight

625.51

Formula

C₃₀H₃₃Cl₂F₃N₄O₃

CAS No.

1780303-76-5

SMILES

CC1=C(C=C(C=C1)NC(C2=CC=C(C(C(F)(F)F)=C2)CN3CCN(CC3)CC)=O)OC4=CC(C5)=C(C=C4)NC5=O.Cl.Cl

Shipping

Room temperature in continental US; may vary elsewhere

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Product Name:
DDR1-IN-1 dihydrochloride
Cat. No.:
HY-13979A
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DDR1-IN-1 dihydrochloride

Cat. No.: HY-13979A