1. Protein Tyrosine Kinase/RTK
  2. Discoidin Domain Receptor
  3. DDR1-IN-6

DDR1-IN-6 

Cat. No.: HY-133670
Handling Instructions

DDR1-IN-6 is a selective Discoidin Domain Receptor family, member 1 (DDR1) inhibitor with an IC50 of 9.72 nM. DDR1-IN-6 inhibits auto-phosphorylation DDR1b (Y513) with an IC50 of 9.7 nM. DDR1-IN-6 has anti-cancer activity.

For research use only. We do not sell to patients.

DDR1-IN-6 Chemical Structure

DDR1-IN-6 Chemical Structure

CAS No. : 2416021-47-9

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Description

DDR1-IN-6 is a selective Discoidin Domain Receptor family, member 1 (DDR1) inhibitor with an IC50 of 9.72 nM. DDR1-IN-6 inhibits auto-phosphorylation DDR1b (Y513) with an IC50 of 9.7 nM. DDR1-IN-6 has anti-cancer activity[1].

IC50 & Target[1]

DDR1

9.72 nM (IC50)

In Vitro

DDR1-IN-6 (compound 1; for 24 hours) inhibits collagen production in human hepatic stellate cell LX-2 (IC50=13 nM)[1].
DDR1-IN-6 (72 hours) has cytotoxicity in LX-2 cells (CC50=3 μM)[1].
DDR1-IN-6 (0-30 μM) has anti-proliferation effects on primary tumor cells freshly isolated from PC-07-0024 (IC50=5.7 μM of 3 days; IC50=2.65 μM of 6 days) and LU-01-0523 derived xenograft (PDX) tumor model (IC50>30 μM of 3 days; IC50>30 μM of 6 days)[1].

Molecular Weight

433.39

Formula

C₂₃H₁₄F₃N₅O

CAS No.

2416021-47-9

SMILES

FC(C1=CC(NC2=NOC3=C2C=CC(C)=C3C#CC4=CN=C5C=CC=NN54)=CC=C1)(F)F

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Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

DDR1-IN-6Discoidin Domain Receptorauto-phosphorylationDDR1bY513anti-cancerhepaticstellateLX-2PC-07-0024LU-01-0523Inhibitorinhibitorinhibit

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DDR1-IN-6
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