1. Protein Tyrosine Kinase/RTK
  2. Discoidin Domain Receptor
  3. DDR1-IN-5

DDR1-IN-5 

Cat. No.: HY-133669
Handling Instructions

DDR1-IN-5 is a selective Discoidin Domain Receptor family, member 1 (DDR1) inhibitor with an IC50 of 7.36 nM. DDR1-IN-5 inhibits auto-phosphorylation DDR1b (Y513) with an IC50 of 4.1 nM. DDR1-IN-5 has anti-cancer activity.

For research use only. We do not sell to patients.

DDR1-IN-5 Chemical Structure

DDR1-IN-5 Chemical Structure

CAS No. : 2416022-90-5

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Description

DDR1-IN-5 is a selective Discoidin Domain Receptor family, member 1 (DDR1) inhibitor with an IC50 of 7.36 nM. DDR1-IN-5 inhibits auto-phosphorylation DDR1b (Y513) with an IC50 of 4.1 nM. DDR1-IN-5 has anti-cancer activity[1].

IC50 & Target[1]

DDR1

7.36 nM (IC50)

In Vitro

DDR1-IN-5 (compound 121; for 24 hours) inhibits collagen production in human hepatic stellate cell LX-2 (IC50=62 nM)[1].
DDR1-IN-5 (72 hours) has cytotoxicity in LX-2 cells (CC50>40 μM)[1].

Molecular Weight

434.37

Formula

C₂₂H₁₃F₃N₆O

CAS No.

2416022-90-5

SMILES

CC1=C(C#CC2=CN=C3N2N=CC=C3)C4=C(C=C1)C(NC5=CN=CC(C(F)(F)F)=C5)=NO4

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

DDR1-IN-5Discoidin Domain Receptorauto-phosphorylationDDR1bY513anti-cancerhepaticstellateLX-2Inhibitorinhibitorinhibit

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