1. Protein Tyrosine Kinase/RTK
  2. Discoidin Domain Receptor

DDR Inhibitor 

Cat. No.: HY-W018931
Handling Instructions

DDR Inhibitor is a potent discoidin domain receptor (DDR) inhibitor, with an IC50 of 3.3 nM for DDR2, and shows 53% inhibition on DDR1 at 1.5 nM.

For research use only. We do not sell to patients.

DDR Inhibitor Chemical Structure

DDR Inhibitor Chemical Structure

CAS No. : 1644069-80-6

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  • Biological Activity

  • Protocol

  • Technical Information

  • Purity & Documentation

  • References

Description

DDR Inhibitor is a potent discoidin domain receptor (DDR) inhibitor, with an IC50 of 3.3 nM for DDR2, and shows 53% inhibition on DDR1 at 1.5 nM.

IC50 & Target

IC50: 3.3 nM (DDR2)[1]
IC53: 1.5 nM (DDR1)[1]

In Vitro

DDR Inhibitor (Example 6) is a potent DDR inhibitor, with an IC50 of 3.3 nM for DDR2, and shows 53% inhibition on DDR1 at 1.5 nM[1].

Solvent & Solubility
In Vitro: 

10 mM in DMSO

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3956 mL 11.9778 mL 23.9555 mL
5 mM 0.4791 mL 2.3956 mL 4.7911 mL
10 mM 0.2396 mL 1.1978 mL 2.3956 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Kinase Assay
[1]

Europium Kinase binding assay is used. Compounds (DDR Inhibitor, etc.) are incubated with 0.5 nM DDR1 or 0.25 nM DDR2 for 1 hour at room temperature in low volume black 384 well assay plates containing 5 nM or 10 nM Kinase Tracer 178 respectively and 2 nM Europium labelled anti-GST antibody in assay buffer (50 mM HEPES pH 7.5, 10 mM MgCl2, 1 mM EGTA and 0.01 % BRIJ35). The ratio of fluorescence emission 665 nm/615 nm after excitation at 340 nm is obtained. IC50 values are determined from dose-response plots using nonlinear least-squares analysis[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References
Molecular Weight

417.44

Formula

C₂₃H₂₀FN₅O₂

CAS No.

1644069-80-6

SMILES

O=C(C1=CN=C2C=CC=CN21)NC3=CC(CNC(NC4=CC=CC(F)=C4)=O)=CC=C3C

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

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This equation is commonly abbreviated as: C1V1 = C2V2

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× = ×
C1   V1   C2   V2

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Product Name:
DDR Inhibitor
Cat. No.:
HY-W018931
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DDR Inhibitor

Cat. No.: HY-W018931