1. Cell Cycle/DNA Damage
  2. CDK
  3. CDK2-IN-4

CDK2-IN-4 

Cat. No.: HY-117535
Handling Instructions

CDK2-IN-4 is a potent and selective CDK2 inhibitor with an IC50 of 44 nM for CDK2/cyclin A, shows 2,000-fold selectivity over CDK1/cyclin B (IC50=86 uM).

For research use only. We do not sell to patients.

CDK2-IN-4 Chemical Structure

CDK2-IN-4 Chemical Structure

CAS No. : 2079895-42-2

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Description

CDK2-IN-4 is a potent and selective CDK2 inhibitor with an IC50 of 44 nM for CDK2/cyclin A, shows 2,000-fold selectivity over CDK1/cyclin B (IC50=86 uM)[1].

IC50 & Target[1]

cdk2/cyclin A

44 nM (IC50)

Cdk1/cyclin B

86 μM (IC50)

Molecular Weight

442.49

Formula

C₂₃H₁₈N₆O₂S

CAS No.

2079895-42-2

SMILES

O=S(C1=CC=C(C=C1)NC2=NC3=NC=NC3=C(C4=CC(C5=CC=CC=C5)=CC=C4)N2)(N)=O

Shipping

Room temperature in continental US; may vary elsewhere

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (282.49 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2599 mL 11.2997 mL 22.5994 mL
5 mM 0.4520 mL 2.2599 mL 4.5199 mL
10 mM 0.2260 mL 1.1300 mL 2.2599 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (4.70 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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CDK2-IN-4
Cat. No.:
HY-117535
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