1. Cell Cycle/DNA Damage
  2. CDK
  3. CDK2-IN-4

CDK2-IN-4 

Cat. No.: HY-117535 Purity: >97.0%
Handling Instructions

CDK2-IN-4 is a potent and selective CDK2 inhibitor with an IC50 of 44 nM for CDK2/cyclin A, shows 2,000-fold selectivity over CDK1/cyclin B (IC50=86 uM).

For research use only. We do not sell to patients.

CDK2-IN-4 Chemical Structure

CDK2-IN-4 Chemical Structure

CAS No. : 2079895-42-2

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 341 In-stock
Estimated Time of Arrival: December 31
5 mg USD 350 In-stock
Estimated Time of Arrival: December 31
10 mg USD 550 In-stock
Estimated Time of Arrival: December 31
50 mg   Get quote  
100 mg   Get quote  

* Please select Quantity before adding items.

Customer Review

Based on 1 publication(s) in Google Scholar

Top Publications Citing Use of Products
  • Biological Activity

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Description

CDK2-IN-4 is a potent and selective CDK2 inhibitor with an IC50 of 44 nM for CDK2/cyclin A, shows 2,000-fold selectivity over CDK1/cyclin B (IC50=86 uM)[1].

IC50 & Target[1]

cdk2/cyclin A

44 nM (IC50)

Cdk1/cyclin B

86 μM (IC50)

Molecular Weight

442.49

Formula

C₂₃H₁₈N₆O₂S

CAS No.

2079895-42-2

SMILES

O=S(C1=CC=C(C=C1)NC2=NC3=NC=NC3=C(C4=CC(C5=CC=CC=C5)=CC=C4)N2)(N)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

DMSO : 20.83 mg/mL (47.07 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2599 mL 11.2997 mL 22.5994 mL
5 mM 0.4520 mL 2.2599 mL 4.5199 mL
10 mM 0.2260 mL 1.1300 mL 2.2599 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (4.70 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: >97.0%

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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× = ×
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Keywords:

CDK2-IN-4CDKCyclin dependent kinaseInhibitorinhibitorinhibit

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Product name:
CDK2-IN-4
Cat. No.:
HY-117535
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