1. Epigenetics
  2. Epigenetic Reader Domain

I-BRD9 

Cat. No.: HY-18975 Purity: 98.09%
Data Sheet SDS Handling Instructions

I-BRD9 is the first selective cellular chemical probe for BRD9 (pIC50=7.3).

For research use only. We do not sell to patients.
I-BRD9 Chemical Structure

I-BRD9 Chemical Structure

CAS No. : 1714146-59-4

Size Price Stock Quantity
10 mM * 1 mL in DMSO $99 In-stock
5 mg $90 In-stock
10 mg $150 In-stock
25 mg $320 In-stock
50 mg $570 In-stock
100 mg $1000 In-stock
200 mg   Get quote  
500 mg   Get quote  

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Description

I-BRD9 is the first selective cellular chemical probe for BRD9 (pIC50=7.3). IC50 value: 7.3 (pIC50) [1] Target: BRD9 in vitro: I-BRD9 is a selective cell active chemical probe for bromodomain containing protein 9 inhibition. I-BRD9, the first selective cellular chemical probe for bromodomain-containing protein 9 (BRD9). I-BRD9 is identified through structure-based design, leading to greater than 700-fold selectivity over the BET family and 200-fold over the highly homologous bromodomain-containing protein 7 (BRD7). I-BRD9 is used to identify genes regulated by BRD9 in Kasumi-1 cells involved in oncology and immune response pathways and to the best of our knowledge, represents the first selective tool compound available to elucidate the cellular phenotype of BRD9 bromodomain inhibition.

References
Preparing Stock Solutions
Concentration Volume (DMSO) Mass 1 mg 5 mg 10 mg
1 mM 2.0098 mL 10.0492 mL 20.0985 mL
5 mM 0.4020 mL 2.0098 mL 4.0197 mL
10 mM 0.2010 mL 1.0049 mL 2.0098 mL
References
Molecular Weight

497.55

Formula

C₂₂H₂₂F₃N₃O₃S₂

CAS No.

1714146-59-4

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

DMSO: 15.5 mg/mL

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

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Product Name:
I-BRD9
Cat. No.:
HY-18975
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