1. Epigenetics
  2. Epigenetic Reader Domain

I-BRD9 

Cat. No.: HY-18975 Purity: 98.09%
Handling Instructions

I-BRD9 is the first selective cellular chemical probe for BRD9 (pIC50=7.3).

For research use only. We do not sell to patients.

I-BRD9 Chemical Structure

I-BRD9 Chemical Structure

CAS No. : 1714146-59-4

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 99 In-stock
Stock in the United States
Estimated Time of Arrival: December 31
5 mg USD 90 In-stock
Stock in the United States
Estimated Time of Arrival: December 31
10 mg USD 150 In-stock
Stock in the United States
Estimated Time of Arrival: December 31
25 mg USD 320 In-stock
Stock in the United States
Estimated Time of Arrival: December 31
50 mg USD 570 In-stock
Stock in the United States
Estimated Time of Arrival: December 31
100 mg USD 1000 In-stock
Stock in the United States
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

Customer Review

  • Biological Activity

  • Protocol

  • Technical Information

  • Purity & Documentation

  • References

Description

I-BRD9 is the first selective cellular chemical probe for BRD9 (pIC50=7.3). IC50 value: 7.3 (pIC50) [1] Target: BRD9 in vitro: I-BRD9 is a selective cell active chemical probe for bromodomain containing protein 9 inhibition. I-BRD9, the first selective cellular chemical probe for bromodomain-containing protein 9 (BRD9). I-BRD9 is identified through structure-based design, leading to greater than 700-fold selectivity over the BET family and 200-fold over the highly homologous bromodomain-containing protein 7 (BRD7). I-BRD9 is used to identify genes regulated by BRD9 in Kasumi-1 cells involved in oncology and immune response pathways and to the best of our knowledge, represents the first selective tool compound available to elucidate the cellular phenotype of BRD9 bromodomain inhibition.

Solvent & Solubility
In Vitro: 

DMSO : 15.5 mg/mL (31.15 mM; Need ultrasonic and warming)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0098 mL 10.0492 mL 20.0985 mL
5 mM 0.4020 mL 2.0098 mL 4.0197 mL
10 mM 0.2010 mL 1.0049 mL 2.0098 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

497.55

Formula

C₂₂H₂₂F₃N₃O₃S₂

CAS No.

1714146-59-4

SMILES

N=C(C(S1)=CC2=C1C(C3=CC=CC(C(F)(F)F)=C3)=CN(CC)C2=O)NC(CC4)CCS4(=O)=O

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

  • Molarity Calculator

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The molarity calculator equation

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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Product Name:
I-BRD9
Cat. No.:
HY-18975
Quantity:

I-BRD9

Cat. No.: HY-18975