Cat. No.: HY-N6954

Garcinone C

2 Cited Publications

Customer Review

Based on 2 publication(s) in Google Scholar

Garcinone C, a xanthone derivative, is a natural compound extracted from Garcinia oblongifolia that is used as an anti-inflammatory, astringency and granulation-promoting medicine, and has potential cytotoxic effects on certain cancers. Garcinone C stimulates the expression levels of ATR and 4E-BP1, arrests the cell cycle, inhibits cell viability of the human Nasopharyngeal carcinoma (NPC) cell lines CNE1, CNE2, HK1 and HONE1 in a time‑ and dose‑dependent manner through inhibition of Hedgehog signaling pathway. Garcinone C is orally active.

For research use only. We do not sell to patients.

Purity: 99.51%
CAS No.: 76996-27-5
Formula: C₂₃H₂₆O₇
Molecular Weight:414.45

Storage:

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Garcinone C Chemical Structure

CAS No.: 76996-27-5

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Publications (2)
Solvent & Solubility
- In Vitro
- In Vivo
Purity & Documentation
References
Help & FAQs
Bioz

Biological Activity

Description

IC₅₀ & Target^[1]

ATR

Stat-3

CDK7

All ATM/ATR Isoforms :

All STAT Isoforms :

All CDK Isoforms :

In Vitro

Garcinone C (1-5 μg/mL; 24 h-2 weeks) inhibits the the expression of cyclin D1, cyclin E and CDK6, increases the expression of p21, arrests the cell cycle at G0/G1 phase, inhibits the colony formation of HT29^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[2]

Cell Line:

HT29
Concentration:

0.3-3 μg/mL
Incubation Time:

24 h
Result:

Reduced the expression of cyclin D1/E and CDK6, increased the expression of p21.

Cell Cycle Analysis^[2]

Cell Line:

HT29
Concentration:

1-5 μg/mL
Incubation Time:

24 h
Result:

Arrested the cell cycle at G0/G1 phase.

In Vivo

Garcinone C (10-50 mg/kg, po, 5 days per week for 9 weeks) exhibits antitumor activity in AOM (HY-111375)/DSS (HY-116282C)-induced colon cancer mouse models^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

AOM/DSS-induced colon cancer mouse models^[2]
Dosage:

10-50 mg/kg
Administration:

po, 5 days per week for 9 weeks
Result:

Reduced the number of colon tumors.

Chemical Information

CAS No. 76996-27-5
Appearance Solid
Molecular Weight 414.45
Formula C₂₃H₂₆O₇
Color Light yellow to yellow
SMILES

CC(C)(O)CCC1=C(O)C(O)=CC(OC2=CC(O)=C(C/C=C(C)/C)C(O)=C23)=C1C3=O
Structure Classification
- Phenols
- Polyphenols
- Phenols
- Xanthones
Initial Source
- Plants
- other families
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Publications (2)

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Journal Impact Factor

EMBO Rep

Nuclear PD-L1 triggers tumour-associated inflammation upon DNA damage. [Abstract]

2025 Feb;26(3):635-655. PMID: 39747659
Food Anal Methods

2023 May 9.

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (241.28 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.4128 mL

12.0642 mL

24.1284 mL

5 mM

0.4826 mL

2.4128 mL

4.8257 mL

10 mM

0.2413 mL

1.2064 mL

2.4128 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Dilution Calculator

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

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Volume _(start) Volume _(start)

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In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)

Solubility: ≥ 2.5 mg/mL (6.03 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

Protocol 2

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 2.5 mg/mL (6.03 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (277 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Xia Y, et al. Garcinone C exerts antitumor activity by modulating the expression of ATR/Stat3/4E BP1 in nasopharyngeal carcinoma cells. Oncol Rep. 2018 Mar;39(3):1485-1493. [Content Brief]

[2]. Chen J, et al., Garcinone C suppresses colon tumorigenesis through the Gli1-dependent hedgehog signaling pathway. Phytomedicine. 2020 Dec;79:153334. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	2.4128 mL	12.0642 mL	24.1284 mL	60.3209 mL
	5 mM	0.4826 mL	2.4128 mL	4.8257 mL	12.0642 mL
	10 mM	0.2413 mL	1.2064 mL	2.4128 mL	6.0321 mL
	15 mM	0.1609 mL	0.8043 mL	1.6086 mL	4.0214 mL
	20 mM	0.1206 mL	0.6032 mL	1.2064 mL	3.0160 mL
	25 mM	0.0965 mL	0.4826 mL	0.9651 mL	2.4128 mL
	30 mM	0.0804 mL	0.4021 mL	0.8043 mL	2.0107 mL
	40 mM	0.0603 mL	0.3016 mL	0.6032 mL	1.5080 mL
	50 mM	0.0483 mL	0.2413 mL	0.4826 mL	1.2064 mL
	60 mM	0.0402 mL	0.2011 mL	0.4021 mL	1.0053 mL
	80 mM	0.0302 mL	0.1508 mL	0.3016 mL	0.7540 mL
	100 mM	0.0241 mL	0.1206 mL	0.2413 mL	0.6032 mL

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Garcinone C

Cell Cycle/DNA Damage Compound Library

Immunology/Inflammation Compound Library

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Kinase Inhibitor Library

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Publications Citing Use of MedChemExpress (MCE) Garcinone C

All ATM/ATR Isoforms

All STAT Isoforms

All CDK Isoforms

Biological Activity

Chemical Information

Publications (2)

Solvent & Solubility

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

Garcinone C Related Classifications

Cat. No.: HY-N6954