2. Cell Cycle/DNA Damage PI3K/Akt/mTOR
  3. ATM/ATR PI3K mTOR
  4. ATM Inhibitor-4

ATM Inhibitor-4 (compound 39) is a potent and selective ATM inhibitor, with an IC50 of 0.32 nM. ATM Inhibitor-4 shows stronger inhibition of PI3K kinases family. ATM Inhibitor-4 shows a full inhibition of mTOR at 1 μM. ATM Inhibitor-4 exhibits favorable metabolic stability.

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ATM Inhibitor-4 Chemical Structure

ATM Inhibitor-4 Chemical Structure

CAS No. : 2769140-74-9

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ATM Inhibitor-4 Related Antibodies

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ATM ATR

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PI3Kα PI3Kβ PI3Kγ PI3Kδ PI3KC2α PI3KC2β PI3KC2γ Vps34 PI3K PI3KC3 p120γ

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mTOR mTORC1 mTORC2

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Description

ATM Inhibitor-4 (compound 39) is a potent and selective ATM inhibitor, with an IC50 of 0.32 nM. ATM Inhibitor-4 shows stronger inhibition of PI3K kinases family. ATM Inhibitor-4 shows a full inhibition of mTOR at 1 μM. ATM Inhibitor-4 exhibits favorable metabolic stability[1].

IC50 & Target

ATM

0.32 nM (IC50)

PI3K

 

mTOR

 

Molecular Weight

492.55

Formula

C26H29FN6O3
CAS No.
SMILES

COCCN1C(N(C2=C1C3=CC(C4=CC=C(C=C4)NC(NCCN5CC(C5)F)=O)=CC=C3N=C2)C)=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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ATM Inhibitor-4 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ATM Inhibitor-42769140-74-9ATM Inhibitor4ATM Inhibitor 4ATM/ATRPI3KmTORAtaxia telangiectasia mutatedATM and RAD3 relatedPhosphoinositide 3-kinaseMammalian target of RapamycinA549 NSCLC cellsDNA damage responseDDRAtaxia-Telangiectasia-mutated kinaseInhibitorinhibitorinhibit

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