2769140-74-9
Chemical Structure
ATM Inhibitor-4
- CAS No.: 2769140-74-9
- Formula:C26H29FN6O3
- Molecular Weight:492.55
IUPAC Name: 1-(2-(3-fluoroazetidin-1-yl)ethyl)-3-(4-(1-(2-methoxyethyl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-c]quinolin-8-yl)phenyl)urea
InChIKey: NHAYGJSVNRVADE-UHFFFAOYSA-N
SMILES: COCCN1C(N(C2=C1C3=CC(C4=CC=C(C=C4)NC(NCCN5CC(C5)F)=O)=CC=C3N=C2)C)=O
Biological Activity: ATM Inhibitor-4 (compound 39) is a potent and selective ATM inhibitor, with an IC50 of 0.32 nM. ATM Inhibitor-4 shows stronger inhibition of PI3K kinases family. ATM Inhibitor-4 shows a full inhibition of mTOR at 1 μM. ATM Inhibitor-4 exhibits favorable metabolic stability[1].
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ATM Inhibitor-4 | ATM Inhibitor-4 (compound 39) is a potent and selective ATM inhibitor, with an IC50 of 0.32 nM. ATM Inhibitor-4 shows stronger inhibition of PI3K kinases family. ATM Inhibitor-4 shows a full inhibition of mTOR at 1 μM. ATM Inhibitor-4 exhibits favorable metabolic stability. | |||||||||||||||||||||
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Keywords
