2. Protein Tyrosine Kinase/RTK Apoptosis Cell Cycle/DNA Damage
  3. Src Bcr-Abl Apoptosis Wee1
  4. PD173952

PD173952 is a tyrosine kinases inhibitor with IC50s of 0.3, 1.7 and 6.6 nM against Lyn, Abl and Csk, respectively. PD173952 is also a potent Myt1 kinase inhibitor with a Ki of 8.1 nM. PD173952 induces apoptosis.

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PD173952 Chemical Structure

PD173952 Chemical Structure

CAS No. : 305820-75-1

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Based on 1 publication(s) in Google Scholar

PD173952 Related Antibodies

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Description

PD173952 is a tyrosine kinases inhibitor with IC50s of 0.3, 1.7 and 6.6 nM against Lyn, Abl and Csk, respectively. PD173952 is also a potent Myt1 kinase inhibitor with a Ki of 8.1 nM. PD173952 induces apoptosis[1][2].

IC50 & Target[1][2]

Lyn

0.3 nM (IC50)

Abl

1.7 nM (IC50)

Csk

6.6 nM (IC50)

Myt1

8.1 nM (Ki)

In Vitro

PD173952 (0-1000 nM; 12 h) inhibits tyrosine phosphorylation of p210Bcr-Abl and CrkL in K562 cells in a concentration-dependent manner[1].
PD173952 (0.5 μM; 1-4 days) inhibits K562 cell viability[1].
PD173952 (0.5 μM; 24 and 48 h) induces apoptosis of K562 and MEG-01 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

PD173952 Related Antibodies

Western Blot Analysis[1]

Cell Line: K562 cells
Concentration: 0, 25, 50, 100, 200, 500 and 1000 nM
Incubation Time: 12 h
Result: Inhibited tyrosine phosphorylation of p210Bcr-Abl and CrkL.

Cell Viability Assay[1]

Cell Line: K562 cells
Concentration: 0.5 μM
Incubation Time: 1-4 days
Result: Caused cell death in a time-dependent manner.

Western Blot Analysis[1]

Cell Line: K562 and MEG-01 cells
Concentration: 0.5 μM
Incubation Time: 24 and 48 h
Result: 85-kDa PARP fragment was detected.
Molecular Weight

482.36

Formula

C24H21Cl2N5O2
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C1C(C2=C(C=CC=C2Cl)Cl)=CC3=CN=C(N=C3N1C)NC4=CC=C(C=C4)N5CCOCC5
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 16.67 mg/mL (34.56 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0731 mL 10.3657 mL 20.7314 mL
5 mM 0.4146 mL 2.0731 mL 4.1463 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.0731 mL 10.3657 mL 20.7314 mL 51.8285 mL
5 mM 0.4146 mL 2.0731 mL 4.1463 mL 10.3657 mL
10 mM 0.2073 mL 1.0366 mL 2.0731 mL 5.1829 mL
15 mM 0.1382 mL 0.6910 mL 1.3821 mL 3.4552 mL
20 mM 0.1037 mL 0.5183 mL 1.0366 mL 2.5914 mL
25 mM 0.0829 mL 0.4146 mL 0.8293 mL 2.0731 mL
30 mM 0.0691 mL 0.3455 mL 0.6910 mL 1.7276 mL
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PD173952 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PD173952305820-75-1PD 173952PD-173952SrcBcr-AblApoptosisWee1LynAblCskMyt1K562MEG-01Inhibitorinhibitorinhibit

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