1. Autophagy
    Apoptosis
    PI3K/Akt/mTOR
  2. Autophagy
    Apoptosis
    PI3K
    Akt
  3. Sophocarpine

Sophocarpine 

Cat. No.: HY-N0103 Purity: >98.0%
Handling Instructions

Sophocarpine is one of the significant alkaloid extracted from the traditional herb medicine Sophora flavescens which has many pharmacological properties such as anti-virus, anti-tumor, anti-inflammatory. Sophocarpine significantly inhibits the growth of gastric cancer (GC) cells through multiple mechanisms such as induction of autophagy, activation of cell apoptosis and down-regulation of cell survival PI3K/AKT signaling pathway. Sophocarpine has been demonstrated to have anti-tumor activity in various cancer cells, including hepatocellular carcinoma, prostate cancer and colorectal cancer.

For research use only. We do not sell to patients.

Sophocarpine Chemical Structure

Sophocarpine Chemical Structure

CAS No. : 6483-15-4

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 55 In-stock
Estimated Time of Arrival: December 31
5 mg USD 50 In-stock
Estimated Time of Arrival: December 31
10 mg USD 80 In-stock
Estimated Time of Arrival: December 31
20 mg USD 140 In-stock
Estimated Time of Arrival: December 31
50 mg   Get quote  
100 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

Sophocarpine is one of the significant alkaloid extracted from the traditional herb medicine Sophora flavescens which has many pharmacological properties such as anti-virus, anti-tumor, anti-inflammatory. Sophocarpine significantly inhibits the growth of gastric cancer (GC) cells through multiple mechanisms such as induction of autophagy, activation of cell apoptosis and down-regulation of cell survival PI3K/AKT signaling pathway. Sophocarpine has been demonstrated to have anti-tumor activity in various cancer cells, including hepatocellular carcinoma, prostate cancer and colorectal cancer[1].

IC50 & Target[1]

PI3K

 

Akt

 

Molecular Weight

246.35

Formula

C₁₅H₂₂N₂O

CAS No.

6483-15-4

SMILES

O=C1C=CC[[email protected]]2([H])[[email protected]@]3([H])CCCN4[[email protected]@]3([H])[[email protected]](CCC4)([H])CN21

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (1014.82 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.0593 mL 20.2963 mL 40.5927 mL
5 mM 0.8119 mL 4.0593 mL 8.1185 mL
10 mM 0.4059 mL 2.0296 mL 4.0593 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (8.44 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (8.44 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (8.44 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

SophocarpineAutophagyApoptosisPI3KAktPhosphoinositide 3-kinasePKBProtein kinase BInhibitorinhibitorinhibit

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Sophocarpine
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HY-N0103
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