1. Protein Tyrosine Kinase/RTK
    PI3K/Akt/mTOR
  2. Src
    FAK
    Akt
  3. SU6656

SU6656 

Cat. No.: HY-B0789 Purity: 96.87%
Handling Instructions

SU6656 is a Src family kinases inhibitor with IC50s of 280, 20, 130, 170 nM for Src, Yes, Lyn, and Fyn, respectively. SU6656 inhibits FAK phosphorylation at Y576/577, Y925, Y861 sites. SU6656 also inhibits p-AKT.

For research use only. We do not sell to patients.

SU6656 Chemical Structure

SU6656 Chemical Structure

CAS No. : 330161-87-0

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Free Sample (0.5-1 mg)   Apply Now  
10 mM * 1 mL in DMSO USD 106 In-stock
Estimated Time of Arrival: December 31
5 mg USD 96 In-stock
Estimated Time of Arrival: December 31
10 mg USD 174 In-stock
Estimated Time of Arrival: December 31
50 mg USD 648 In-stock
Estimated Time of Arrival: December 31
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Customer Review

Based on 4 publication(s) in Google Scholar

Top Publications Citing Use of Products

    SU6656 purchased from MCE. Usage Cited in: Biochim Biophys Acta Mol Basis Dis. 2018 Nov;1864(11):3824-3836.

    NRK-49F cells are pretreated with Fyn inhibitor SU6656 (1 μM) for 30 min, followed by TGF-β1 stimulation for 12 h, and then protein levels of fibronectin and α-SMA are determined by Western blotting.

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    Description

    SU6656 is a Src family kinases inhibitor with IC50s of 280, 20, 130, 170 nM for Src, Yes, Lyn, and Fyn, respectively. SU6656 inhibits FAK phosphorylation at Y576/577, Y925, Y861 sites. SU6656 also inhibits p-AKT.

    In Vitro

    SU6656 decreases phosphorylation of Src family kinases (SFKs) in HNSCC cells[2].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    In Vivo

    SU6656 (2-4 mg/kg; i.p.; once) significantly decreases ischemic postconditioning (IPoCo) mediated increase in fall down time[5].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Swiss albino male mice[5]
    Dosage: 2, 4 mg/kg
    Administration: Intraperitoneal injection; once
    Result: Significantly decreased IPoCo mediated increase in fall down time.
    Molecular Weight

    371.45

    Formula

    C₁₉H₂₁N₃O₃S

    CAS No.

    330161-87-0

    SMILES

    O=S(C1=CC2=C(NC(/C2=C\C(N3)=CC4=C3CCCC4)=O)C=C1)(N(C)C)=O

    Shipping

    Room temperature in continental US; may vary elsewhere.

    Storage
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 6 months
    -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    DMSO : 20 mg/mL (53.84 mM; Need ultrasonic)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 2.6922 mL 13.4608 mL 26.9215 mL
    5 mM 0.5384 mL 2.6922 mL 5.3843 mL
    10 mM 0.2692 mL 1.3461 mL 2.6922 mL
    *Please refer to the solubility information to select the appropriate solvent.
    In Vivo:
    • 1.

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

      Solubility: ≥ 2 mg/mL (5.38 mM); Clear solution

    *All of the co-solvents are provided by MCE.
    References
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    • Molarity Calculator

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    Keywords:

    SU6656SU 6656SU-6656SrcFAKAktPTK2 protein tyrosine kinase 2PTK2Focal adhesion kinasePKBProtein kinase BInhibitorinhibitorinhibit

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    Product Name:
    SU6656
    Cat. No.:
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