1. Protein Tyrosine Kinase/RTK
  2. Src
  3. A-770041

A-770041 

Cat. No.: HY-11011 Purity: 99.53%
Handling Instructions

A-770041 is selective and orally active Src-family Lck inhibitor; A-770041 is a 147 nM inhibitor of Lck (1 mM ATP) and is 300-fold selective against Fyn, the other Src family kinase involved in T-cell signaling.

For research use only. We do not sell to patients.

A-770041 Chemical Structure

A-770041 Chemical Structure

CAS No. : 869748-10-7

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 438 In-stock
Estimated Time of Arrival: December 31
5 mg USD 320 In-stock
Estimated Time of Arrival: December 31
10 mg USD 540 In-stock
Estimated Time of Arrival: December 31
50 mg   Get quote  
100 mg   Get quote  

* Please select Quantity before adding items.

Customer Review

Based on 1 publication(s) in Google Scholar

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Description

A-770041 is selective and orally active Src-family Lck inhibitor; A-770041 is a 147 nM inhibitor of Lck (1 mM ATP) and is 300-fold selective against Fyn, the other Src family kinase involved in T-cell signaling. IC50 value: 147 nM Target: Lck

Molecular Weight

621.73

Formula

C₃₄H₃₉N₉O₃

CAS No.

869748-10-7

SMILES

NC1=C2C(N([[email protected]@H]3CC[[email protected]@H](N4CCN(C(C)=O)CC4)CC3)N=C2C5=CC=C(NC(C6=CC7=C(C=CC=C7)N6C)=O)C(OC)=C5)=NC=N1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (160.84 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.6084 mL 8.0421 mL 16.0842 mL
5 mM 0.3217 mL 1.6084 mL 3.2168 mL
10 mM 0.1608 mL 0.8042 mL 1.6084 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (4.02 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (4.02 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (4.02 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

A-770041A770041A 770041SrcInhibitorinhibitorinhibit

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Product Name:
A-770041
Cat. No.:
HY-11011
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