FYN
FYN is a ubiquitously expressed Src-family tyrosine kinase bearing the canonical myristoylated SH3-SH2-kinase architecture, with brain-enriched and epithelial isoforms produced by alternative splicing. In T lymphocytes, FYN phosphorylates T-cell receptor chains including the zeta subunit and collaborates with LCK in antigen receptor signaling. In the central nervous system, FYN drives oligodendrocyte differentiation and myelination, organizes postsynaptic densities through scaffolds such as PSD-95, modulates NMDA-type glutamate receptors, and phosphorylates tau, connecting it to Alzheimer disease; the FYN inhibitor saracatinib entered Alzheimer clinical trials. FYN additionally participates in platelet activation and focal adhesion signaling, illustrating its broad reach across excitable and immune tissues.
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FYN Recombinant Proteins (1)
- Species:
- Source:
Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formel: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
