Discovery of A-770041, a src-family selective orally active lck inhibitor that prevents organ allograft rejection

  • Bioorg Med Chem Lett. 2006 Jan 1;16(1):118-22. doi: 10.1016/j.bmcl.2005.09.039.
Andrew Burchat  1 ,  David W Borhani ,  David J Calderwood ,  Gavin C Hirst ,  Biqin Li ,  Robert F Stachlewitz
Affiliations
  • 1. Abbott Bioresearch Center, 100 Research Drive, Worcester, MA 01605-5314, USA.
PMID: 16216497 DOI: 10.1016/j.bmcl.2005.09.039
Abstract

We describe the identification, SAR, and pharmacology of the src-family selective Lck Inhibitor A-770041 that prolongs the survival of major histocompatibility mismatched allografts in models of solid organ transplant rejection for greater than 65 days.

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