1. Protein Tyrosine Kinase/RTK
  2. Src
  3. Src Inhibitor 1

Src Inhibitor 1  (Synonyms: Src Kinase Inhibitor 1; Src-l1)

Cat. No.: HY-101053 Purity: 99.96%
COA Handling Instructions

Src Inhibitor 1 is a potent, ATP-competitive and selective dual site Src tyrosine kinase inhibitor with IC50 values of 44 nM for Src and 88nM for Lck.

For research use only. We do not sell to patients.

Src Inhibitor 1 Chemical Structure

Src Inhibitor 1 Chemical Structure

CAS No. : 179248-59-0

Size Price Stock Quantity
Solution
10 mM * 1 mL in DMSO USD 69 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 69 In-stock
Estimated Time of Arrival: December 31
Solid
2 mg USD 60 In-stock
Estimated Time of Arrival: December 31
5 mg USD 84 In-stock
Estimated Time of Arrival: December 31
10 mg USD 114 In-stock
Estimated Time of Arrival: December 31
25 mg USD 264 In-stock
Estimated Time of Arrival: December 31
50 mg USD 474 In-stock
Estimated Time of Arrival: December 31
100 mg   Get quote  
200 mg   Get quote  

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Customer Review

Based on 10 publication(s) in Google Scholar

Top Publications Citing Use of Products

    Src Inhibitor 1 purchased from MCE. Usage Cited in: Int Immunopharmacol. December 2022, 109340.

    SRC inhibitor 1 (5 μM) significantly reduces SRC phosphorylation in the mouse chondrocytes.
    • Biological Activity

    • Protocol

    • Purity & Documentation

    • References

    • Customer Review

    Description

    Src Inhibitor 1 is a potent, ATP-competitive and selective dual site Src tyrosine kinase inhibitor with IC50 values of 44 nM for Src and 88nM for Lck.

    IC50 & Target

    IC50: 44 nM (Src), 88 nM (Lck)[1]

    In Vitro

    Src-I1 is competitive with both ATP and peptide binding sites of the kinase. The IC50 values are 44 and 88 nM for Src and Lck, respectively[1]. Src-I1, is found to be a potent inhibitor of Src (IC50=0.18 μM), but also inhibited other Src family members, such as Lck, Csk and Yes with similar potency to Src, and RIP2 (IC50=0.026 μM) with even greater potency. In addition, it inhibited CHK2 with similar potency to Src, and Aurora B with slightly lower potency[2].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Molecular Weight

    373.40

    Formula

    C22H19N3O3

    CAS No.
    SMILES

    COC1=CC2=NC=NC(NC3=CC=C(OC4=CC=CC=C4)C=C3)=C2C=C1OC

    Shipping

    Room temperature in continental US; may vary elsewhere.

    Storage
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 6 months
    -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    DMSO : 9.09 mg/mL (24.34 mM; Need ultrasonic)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 2.6781 mL 13.3905 mL 26.7809 mL
    5 mM 0.5356 mL 2.6781 mL 5.3562 mL
    10 mM 0.2678 mL 1.3390 mL 2.6781 mL
    *Please refer to the solubility information to select the appropriate solvent.
    In Vivo:
    • 1.

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

      Solubility: ≥ 0.91 mg/mL (2.44 mM); Clear solution

    • 2.

      Add each solvent one by one:  10% DMSO    90% corn oil

      Solubility: ≥ 0.91 mg/mL (2.44 mM); Clear solution

    *All of the co-solvents are available by MCE.
    Purity & Documentation
    References
    Kinase Assay
    [2]

    Assays (25.5 μL volume) are carried out robotically at room temperature (21°C) and are linear with respect to time and enzyme concentration under the conditions used. Assays are performed for 30 min using Multidrop Micro reagent dispensers in a 96-well format. The concentration of magnesium acetate in the assays is 10 mM and [γ-33P]ATP (800 c.p.m./pmol) is used at 5, 20 or 50 μM as indicated, in order to be at or below the Kmfor ATP for each enzyme.The assays are initiated with MgATP, stopped by the addition of 5 μL of 0.5 M orthophosphoric acid and spotted on to P81 filter plates using a unifilter harvester. The IC50 values of inhibitors are determined after carrying out assays at ten different concentrations of each compound[2].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    References
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    Product Name:
    Src Inhibitor 1
    Cat. No.:
    HY-101053
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