1. Protein Tyrosine Kinase/RTK
  2. Src
  3. Src Inhibitor 1

Src Inhibitor 1 (Synonyms: Src Kinase Inhibitor 1; Src-l1)

Cat. No.: HY-101053 Purity: 99.98%
Handling Instructions

Src Inhibitor 1 is a potent and selective dual site Src tyrosine kinase inhibitor with IC50 values of 44 nM for Src and 88nM for Lck.

For research use only. We do not sell to patients.

Src Inhibitor 1 Chemical Structure

Src Inhibitor 1 Chemical Structure

CAS No. : 179248-59-0

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 69 In-stock
Estimated Time of Arrival: December 31
2 mg USD 60 In-stock
Estimated Time of Arrival: December 31
5 mg USD 84 In-stock
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10 mg USD 114 In-stock
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25 mg USD 264 In-stock
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50 mg USD 474 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

Src Inhibitor 1 is a potent and selective dual site Src tyrosine kinase inhibitor with IC50 values of 44 nM for Src and 88nM for Lck.

IC50 & Target

IC50: 44 nM (Src), 88 nM (Lck)[1]

In Vitro

Src-I1 is competitive with both ATP and peptide binding sites of the kinase. The IC50 values are 44 and 88 nM for Src and Lck, respectively[1]. Src-I1, is found to be a potent inhibitor of Src (IC50=0.18 μM), but also inhibited other Src family members, such as Lck, Csk and Yes with similar potency to Src, and RIP2 (IC50=0.026 μM) with even greater potency. In addition, it inhibited CHK2 with similar potency to Src, and Aurora B with slightly lower potency[2].

Molecular Weight

373.40

Formula

C₂₂H₁₉N₃O₃

CAS No.

179248-59-0

SMILES

COC1=CC2=NC=NC(NC3=CC=C(OC4=CC=CC=C4)C=C3)=C2C=C1OC

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 9.09 mg/mL (24.34 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6781 mL 13.3905 mL 26.7809 mL
5 mM 0.5356 mL 2.6781 mL 5.3562 mL
10 mM 0.2678 mL 1.3390 mL 2.6781 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 0.91 mg/mL (2.44 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 0.91 mg/mL (2.44 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
Kinase Assay
[2]

Assays (25.5 μL volume) are carried out robotically at room temperature (21°C) and are linear with respect to time and enzyme concentration under the conditions used. Assays are performed for 30 min using Multidrop Micro reagent dispensers in a 96-well format. The concentration of magnesium acetate in the assays is 10 mM and [γ-33P]ATP (800 c.p.m./pmol) is used at 5, 20 or 50 μM as indicated, in order to be at or below the Kmfor ATP for each enzyme.The assays are initiated with MgATP, stopped by the addition of 5 μL of 0.5 M orthophosphoric acid and spotted on to P81 filter plates using a unifilter harvester. The IC50 values of inhibitors are determined after carrying out assays at ten different concentrations of each compound[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References
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KeyWords:

Src Inhibitor 1 | Src Kinase Inhibitor 1 | Src-l1 | Src Inhibitor1 | Src Inhibitor-1 | Src Kinase Inhibitor1 | Src Kinase Inhibitor-1 | Src | Inhibitor | inhibitor | inhibit

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Product name:
Src Inhibitor 1
Cat. No.:
HY-101053
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