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Ponatinib hydrochloride

(Synonyms: AP24534 hydrochloride)
56 Cited Publications
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Based on 56 publication(s) in Google Scholar

Ponatinib hydrochloride (AP24534 hydrochloride) is a hydrochloride of ponatinib. Ponatinib is an orally active multi-targeted kinase inhibitor with IC50s of 0.37 nM, 1.1 nM, 1.5 nM, 2.2 nM, and 5.4 nM for Abl, PDGFRα, VEGFR2, FGFR1, and Src, respectively.

For research use only. We do not sell to patients.

  • Purity: 99.76%
  • CAS No.: 1114544-31-8
  • Formula: C29H28ClF3N6O
  • Molecular Weight:569.02
  • Storage:

    4°C, sealed storage, away from moisture

    * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

  • Ponatinib hydrochloride Chemical Structure
    Ponatinib hydrochloride Chemical Structure
  • Experimental Validation Results for Ponatinib hydrochloride
  • Experimental Validation Results for Ponatinib hydrochloride
  • Experimental Validation Results for Ponatinib hydrochloride
  • Experimental Validation Results for Ponatinib hydrochloride
  • Experimental Validation Results for Ponatinib hydrochloride
  • Experimental Validation Results for Ponatinib hydrochloride
  • Experimental Validation Results for Ponatinib hydrochloride
CAS No.: 1114544-31-8
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Find Your Local Distributor Your local distributor: Hycultec GmbHHycultec
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WBCell Imaging/StainingIn Vivo Efficacy StudyCell Proliferation/Viability Assay
  • Cell Proliferation/Viability Assay
  • Cell Proliferation/Viability Assay
  • Cell Imaging/Staining
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  • Ponatinib hydrochloride Chemical Structure
    Ponatinib hydrochloride Chemical Structure
    1/16
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    Ponatinib hydrochloride purchased from MedChemExpress. Usage Cited in: Int J Biol Macromol. 2024 Dec 2:138305. [Abstract]

    Customer Validation
     KBM5-T315I cells were treated with the indicated concentrations of CX-4945, Ponatinib (0.001-10 μM), or with two combined drugs by simultaneously increasing their concentration at the ratio of 1:500 for Ponatinib + CX-4945. Viability was assessed by the MTT method after 48 h treatment and expressed as percentage of vehicle-treated controls.

  • 1/16

    Ponatinib hydrochloride purchased from MedChemExpress. Usage Cited in: Biomed Pharmacother. 2024 Nov:180:117569. [Abstract]

    Customer Validation
     Ponatinib inhibited proliferation of CCA cell lines. Relative viability (%) of KKU-100 and KKU-213A cells after 48 h treatment with buparlisib, Ponatinib and the combination of both drugs (0.25-5 μM).

  • 1/16

    Ponatinib hydrochloride purchased from MedChemExpress. Usage Cited in: Biomed Pharmacother. 2024 Nov:180:117569. [Abstract]

    Customer Validation
     Intracellular ROS in KKU-100 and KKU-213A cells after exposure to 0.75 μM Buparlisib, 0.75 μM Ponatinib and the combination of both for 6 h was measured by fluorescence microscopy using DCFH-DA staining.

  • 1/16

    Ponatinib hydrochloride purchased from MedChemExpress. Usage Cited in: Biomed Pharmacother. 2024 Nov:180:117569. [Abstract]

    Customer Validation
     Representative image of tumors dissected from KKU-213A xenograft mice after 14 days of treatment with Buparlisib (15 mg/kg/day), Ponatinib (30 mg/kg/day) and their combination.

  • 1/16

    Ponatinib hydrochloride purchased from MedChemExpress. Usage Cited in: Acta Pharm Sin B. 2023 Oct;13(10):4253-4272. [Abstract]

    Customer Validation
     BxPC-3, PANC-1 and H6c7 cells were treated with ponatinib (0.1–20 μM) for 24 h, and then cell viability was analyzed by CCK-8 assay.

  • 1/16

    Ponatinib hydrochloride purchased from MedChemExpress. Usage Cited in: Acta Pharm Sin B. 2023 Oct;13(10):4253-4272. [Abstract]

    Customer Validation
     PANC-1 cells were treated with Ponatinib (5-20 μM) or Perifosine (30-70 μM) for 24 h, and total cellular extracts were subjected to Western blot analyses using antibodies against GSDMD and β-tubulin.

  • 1/16

    Ponatinib hydrochloride purchased from MedChemExpress. Usage Cited in: Exp Hematol. 2014 May;42(5):369-379.e3. [Abstract]

    Customer Validation
     Phosphorylation levels of F/P (or its mutant), STAT5, or ERK in lysates of CMPs expressing Hes1 with F/P, F/P-D842V, or F/P-T674I, which have been treated with indicated doses of Ponatinib (0.1-1 μM) for 15 min. Data are representative of three independent experiments.

  • Ponatinib hydrochloride