1. Protein Tyrosine Kinase/RTK
    Autophagy
  2. Bcr-Abl
    FGFR
    PDGFR
    VEGFR
    Src
    Autophagy
  3. Ponatinib hydrochloride

Ponatinib hydrochloride (Synonyms: AP24534 hydrochloride)

Cat. No.: HY-108766
Handling Instructions

Ponatinib (AP24534) hydrochloride is a hydrochloride of ponatinib. Ponatinib is an orally active multi-targeted kinase inhibitor with IC50s of 0.37 nM, 1.1 nM, 1.5 nM, 2.2 nM, and 5.4 nM for Abl, PDGFRα, VEGFR2, FGFR1, and Src, respectively.

For research use only. We do not sell to patients.

Ponatinib hydrochloride Chemical Structure

Ponatinib hydrochloride Chemical Structure

CAS No. : 1114544-31-8

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Customer Review

Based on 19 publication(s) in Google Scholar

Other Forms of Ponatinib hydrochloride:

Top Publications Citing Use of Products

    Ponatinib hydrochloride purchased from MCE. Usage Cited in: Exp Hematol. 2014 May;42(5):369-379.e3.

    (B,D) Phosphorylation levels of F/P (or its mutant), STAT5, or ERK in lysates of CMPs expressing Hes1 with F/P, F/P-D842V, or F/P-T674I, which have been treated with indicated doses of (B) Imatinib or (D) Ponatinib for 15 min. Data are representative of three independent experiments.

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    Description

    Ponatinib (AP24534) hydrochloride is a hydrochloride of ponatinib. Ponatinib is an orally active multi-targeted kinase inhibitor with IC50s of 0.37 nM, 1.1 nM, 1.5 nM, 2.2 nM, and 5.4 nM for Abl, PDGFRα, VEGFR2, FGFR1, and Src, respectively[1].

    IC50 & Target

    LYN

    0.24 nM (IC50)

    Abl

    0.37 nM (IC50)

    PDGFRα

    1.1 nM (IC50)

    VEGFR2

    1.5 nM (IC50)

    FGFR1

    2.2 nM (IC50)

    Src

    5.4 nM (IC50)

    Molecular Weight

    569.02

    Formula

    C29H28ClF3N6O

    CAS No.
    SMILES

    O=C(C1=CC=C(C)C(C#CC2=CN=C3C=CC=NN23)=C1)NC4=CC=C(CN5CCN(CC5)C)C(C(F)(F)F)=C4.Cl

    Shipping

    Room temperature in continental US; may vary elsewhere.

    Storage

    4°C, sealed storage, away from moisture

    *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

    References
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    Product Name:
    Ponatinib hydrochloride
    Cat. No.:
    HY-108766
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