1. Signaling Pathways
  2. Protein Tyrosine Kinase/RTK
  3. PDGFR
  4. PDGFRα Inhibitors

PDGFRα Inhibitors

PDGFR

PDGFRβ

PDGFRα

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Sorry. There is currently no product that acts on isoform PDGFRα together.

Please try each isoform separately.

PDGFRα Specific Inhibitors
Product Name PDGFRα PDGFRβ PDGFRα Selectivity Purity
Ripretinib
PDGFRA
  Selective Inhibitor 98.90%
Amuvatinib
PDGFRαV561D, IC50: 40 nM
PDGFRαD842V, IC50: 81 nM
  Selective Inhibitor 98.07%
ENMD-2076
PDGFRα, IC50: 56.4 nM
  Selective Inhibitor 99.12%
ENMD-2076 Tartrate
PDGFRα, IC50: 56.4 nM
  Selective Inhibitor 98.87%
Tyrosine kinase-IN-1
PDGFRα, IC50: 4 nM
  Selective Inhibitor 99.47%
PDGFRα kinase inhibitor 1
PDGFRα, IC50: 132 nM
PDGFRβ, IC50: 6115 nM
Selective Inhibitor 99.90%
Telatinib mesylate
PDGFRα, IC50: 15 nM
  Selective Inhibitor
Amuvatinib hydrochloride
PDGFRαV561D, IC50: 40 nM
PDGFRαD842V, IC50: 81 nM
  Selective Inhibitor
Lenvatinib
PDGFRα, IC50: 51 nM
PDGFRβ, IC50: 39 nM
Pan Inhibitor 99.87%
Nintedanib
PDGFRα, IC50: 59 nM
PDGFRβ, IC50: 65 nM
Pan Inhibitor 99.97%
Ilorasertib
PDGFRα, IC50: 11 nM
PDGFRβ, IC50: 13 nM
Pan Inhibitor ≥98.0%
Ponatinib
PDGFRα, IC50: 1.1 nM
  Pan Inhibitor 99.13%
Crenolanib
PDGFRα, Kd: 2.1 nM
PDGFRβ, Kd: 3.2 nM
Pan Inhibitor 99.67%
Nintedanib esylate
PDGFRα, IC50: 59 nM
PDGFRβ, IC50: 65 nM
Pan Inhibitor 99.93%
Cediranib
PDGFRα, IC50: 36 nM
PDGFRβ, IC50: 5 nM
Pan Inhibitor ≥98.0%
Dovitinib
PDGFRα, IC50: 27 nM
PDGFRβ, IC50: 210 nM
Pan Inhibitor 99.94%
CP-673451
PDGFRα, IC50: 10 nM
PDGFRβ, IC50: 1 nM
Pan Inhibitor 99.65%
Lenvatinib mesylate
PDGFRα, IC50: 51 nM
PDGFRβ, IC50: 39 nM
Pan Inhibitor 99.86%
Ilorasertib hydrochloride
PDGFRα, IC50: 11 nM
PDGFRβ, IC50: 13 nM
Pan Inhibitor 98.91%
TAK-593
PDGFRα, IC50: 4.3 nM
PDGFRαV561D, IC50: 1 nM
PDGFRβ, IC50: 13 nM
Pan Inhibitor 99.62%
Dovitinib lactate
PDGFRα, IC50: 27 nM
PDGFRβ, IC50: 210 nM
Pan Inhibitor 99.96%
Telatinib
PDGFRα, IC50: 15 nM
  Pan Inhibitor 98.72%
Cediranib maleate
PDGFRα, IC50: 36 nM
PDGFRβ, IC50: 5 nM
Pan Inhibitor 99.74%
JNJ-10198409
PDGFRα, IC50: 45 nM
PDGFRβ, IC50: 4.2 nM
Pan Inhibitor ≥99.0%
AC710
PDGFRα, Kd: 1.3 nM
PDGFRβ, Kd: 1 nM
Pan Inhibitor 99.89%
Tyrphostin AG1296
PDGFRα
PDGFRβ
Pan Inhibitor 99.25%
Hypothemycin
PDGFRα, Ki: 1.5 μM
PDGFRβ, Ki: 900 nM
Pan Inhibitor
Dovitinib lactate hydrate
PDGFRα, IC50: 27 nM
PDGFRβ, IC50: 210 nM
Pan Inhibitor
GZD856
PDGFRα, IC50: 68.6 nM
PDGFRβ, IC50: 136.6 nM
Pan Inhibitor
GZD856 formic
PDGFRα, IC50: 68.6 nM
PDGFRβ, IC50: 136.6 nM
Pan Inhibitor 98.06%
KG5
PDGFRα, Kd: 300 nM
PDGFRβ, Kd: 520 nM
Pan Inhibitor
HG-7-85-01
PDGFRα, IC50: 440 nM
  Pan Inhibitor
Ponatinib D8
PDGFRα, IC50: 1.1 nM
  Pan Inhibitor
AC710 Mesylate
PDGFRα, Kd: 1.3 nM
PDGFRβ, Kd: 1 nM
Pan Inhibitor