656247-18-6
Chemical Structure
Nintedanib esylate
Synonym(s): BIBF 1120 esylate
- CAS. Nr.: 656247-18-6
- Formula:C33H39N5O7S
- Molecular Weight:649.76
IUPAC Name: methyl (Z)-3-(((4-(N-methyl-2-(4-methylpiperazin-1-yl)acetamido)phenyl)amino)(phenyl)methylene)-2-oxoindoline-6-carboxylate ethanesulfonate
InChIKey: MMMVNAGRWOJNMW-FJBFXRHMSA-N
SMILES: O=C(C1=CC(NC/2=O)=C(C=C1)C2=C(NC3=CC=C(N(C)C(CN4CCN(C)CC4)=O)C=C3)/C5=CC=CC=C5)OC.CCS(=O)(O)=O
Biological Activity: Nintedanib esylate (BIBF 1120 esylate) is a potent triple angiokinase inhibitor for VEGFR1/2/3, FGFR1/2/3 and PDGFRα/β with IC50s of 34 nM/13 nM/13 nM, 69 nM/37 nM/108 nM and 59 nM/65 nM, respectively.
| Art. -Nr. | Produktname | Reinheit | Beschreibung | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
Nintedanib esylate | 99.96% | Nintedanib esylate (BIBF 1120 esylate) is a potent triple angiokinase inhibitor for VEGFR1/2/3, FGFR1/2/3 and PDGFRα/β with IC50s of 34 nM/13 nM/13 nM, 69 nM/37 nM/108 nM and 59 nM/65 nM, respectively. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Nintedanib esylate (Standard) | 99.92% | Nintedanib esylate (Standard) is the analytical standard of Nintedanib esylate. This product is intended for research and analytical applications. Nintedanib esylate (BIBF 1120 esylate) is a potent triple angiokinase inhibitor for VEGFR1/2/3, FGFR1/2/3 and PDGFRα/β with IC50s of 34 nM/13 nM/13 nM, 69 nM/37 nM/108 nM and 59 nM/65 nM, respectively. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Nintedanib esylate-d3 | Nintedanib-d3 (BIBF 1120-d3) esylate is the deuterated-labeled Nintedanib esylate (HY-11106). Nintedanib esylate (BIBF 1120 esylate) is a potent triple angiokinase inhibitor for VEGFR1/2/3, FGFR1/2/3 and PDGFRα/β with IC50s of 34 nM/13 nM/13 nM, 69 nM/37 nM/108 nM and 59 nM/65 nM, respectively. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
-
Similarity Score 0.92
HY-50904RNintedanib (Standard) -
Similarity Score 0.87
HY-15992BIBF 1202 -
Similarity Score 0.85
HY-50904SNintedanib-d3 -
Similarity Score 0.85
HY-Z4535Nintedanib impurity 6 -
Similarity Score 0.84
HY-163536TGF-β1/Smad3-IN-1 -
Similarity Score 0.82
HY-101515RMELK-IN-1 (Standard) -
Similarity Score 0.76
HY-Z4752Nintedanib impurity 3 -
Similarity Score 0.72
HY-147243Ansornitinib -
Similarity Score 0.72
HY-50904S2Nintedanib-d8 -
Explore the MedChemAI to find more analogs
