Copy Link Print Information

Nintedanib esylate

(Synonyms: BIBF 1120 esylate)
74 Cited Publications
Customer Review

Based on 74 publication(s) in Google Scholar

Nintedanib esylate (BIBF 1120 esylate) is a potent triple angiokinase inhibitor for VEGFR1/2/3, FGFR1/2/3 and PDGFRα/β with IC50s of 34 nM/13 nM/13 nM, 69 nM/37 nM/108 nM and 59 nM/65 nM, respectively.

For research use only. We do not sell to patients.

  • Purity: 99.96%
  • CAS No.: 656247-18-6
  • Formula: C33H39N5O7S
  • Molecular Weight:649.76
  • Storage:

    4°C, sealed storage, away from moisture

    * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

  • Nintedanib esylate Chemical Structure
    Nintedanib esylate Chemical Structure
  • Experimental Validation Results for Nintedanib esylate
  • Experimental Validation Results for Nintedanib esylate
  • Experimental Validation Results for Nintedanib esylate
  • Experimental Validation Results for Nintedanib esylate
  • Experimental Validation Results for Nintedanib esylate
  • Experimental Validation Results for Nintedanib esylate
CAS No.: 656247-18-6
Size
Price
Stock
Quantity
Amount: USD 0.00
Please select quantity
or
or

* Please select Quantity before adding items.

To place orders, for customer services and technical support, please contact: MedChemExpress USA

Tel: 609-228-6898 E-mail: [email protected] [email protected]

Data Download
Other Forms of Nintedanib esylate:

To place orders, for customer services and technical support, please contact:

609-228-6898
[email protected] [email protected]
Find Your Local Distributor Your local distributor: Hycultec GmbHHycultec
  • Biological Activity
  • Chemical Information
  • Solvent & Solubility
  • Protocol
  • Purity & Documentation
  • References
  • Help & FAQs
You May Still Need
Top Publications Citing

Use of MCE Products

Publications Citing Use of MedChemExpress (MCE) Nintedanib esylate

More
Customer Validation & Images
Cell Imaging/StainingIn Vivo Efficacy StudyCell Proliferation/Viability AssayHistological Imaging/StainingWB
  • Cell Imaging/Staining
  • Cell Proliferation/Viability Assay
  • In Vivo Efficacy Study
  • Histological Imaging/Staining
  • WB
  • Cell Proliferation/Viability Assay

All PDGFR Isoforms

More

All VEGFR Isoforms

More
Keywords
MOQ
Minimum order quantity
100 mg

Get Quote In-stock

Other size
Get Quote
Please select quantity
Amount: USD 0.00
Sign in to MedChemExpress Sign In
Register
Sign in to MedChemExpress
Register New Account

At least 6 characters

Personalize your experience, you are currently not signed in. For a better experience, please create an online profile, you can:

Obtain points redemption prizes
Check out faster
Add multiple shipping locations
View orders
Assay Types
  • Nintedanib esylate Chemical Structure
    Nintedanib esylate Chemical Structure
    1/16
  • 1/16

    Nintedanib esylate purchased from MedChemExpress. Usage Cited in: Bioact Mater. 2023 Nov 22:33:262-278. [Abstract]

    Customer Validation
     CLSM images of E-cadherin immunostaining in A549 cells after TGF-β (10 ng/mL) stimulation with Nintedanib (10 μM), PF (50 μM), n-PN (10 μM), and p-LP (50 μM) for 48 h were obtained.

  • 1/16

    Nintedanib esylate purchased from MedChemExpress. Usage Cited in: Bioact Mater. 2023 Nov 22:33:262-278. [Abstract]

    Customer Validation
     Cell growth inhibition of nintedanib (48 h), PF, n-PN, and p-LP at various concentrations in NIH/3T3 fibroblasts was assessed using an MTT assay.

  • 1/16

    Nintedanib esylate purchased from MedChemExpress. Usage Cited in: Sci Transl Med. 2022 Sep 28;14(664):eabo5070. [Abstract]

    Customer Validation
     Nintedanib (60 mg/kg). Mice were dosed once daily by oral gavage with either 100 μL of the suspension, and animals were monitored for weight loss.

  • 1/16

    Nintedanib esylate purchased from MedChemExpress. Usage Cited in: Sci Transl Med. 2022 Sep 28;14(664):eabo5070. [Abstract]

    Customer Validation
     Nintedanib (60 mg/kg). Mice were dosed once daily by oral gavage with either 100 μL of the suspension, and histopathological analysis of lungs was performed.

  • 1/16

    Nintedanib esylate purchased from MedChemExpress. Usage Cited in: Sci Rep. 2018 Jun 22;8(1):9540. [Abstract]

    Customer Validation
     Western blot based detection of cell cycle associated molecules viz., Cyclins A, D1 and E, and CDKs 2, 4 and 6 in PC3, and LNCaP cells after 72 hours of Nintedanib treatment.

  • 1/16

    Nintedanib esylate purchased from MedChemExpress. Usage Cited in: Oncol Rep. 2016 Dec;36(6):3123-3130. [Abstract]

    Customer Validation
     The mice are treated with TFTD alone (150 mg/kg, orally twice daily from days 1 to 14, open column), or a combination of TFTD and Nintedanib (closed column). The HT-29 and HCT116 tumors are collected at 24 h following the final administration of the drugs (day 15). The values indicate the mean ± SD (n=6).

  • Nintedanib esylate