Clavukoellians A-F, Highly Rearranged Nardosinane Sesquiterpenoids with Antiangiogenic Activity from Clavularia koellikeri

  • J Nat Prod. 2019 May 24;82(5):1331-1337. doi: 10.1021/acs.jnatprod.9b00100.
Qi Wang  1  2 ,  Zhenquan Hu  1 ,  Xiangchao Luo  3 ,  Jing Liu  1 ,  Guoqiang Li  3 ,  Shugeng Cao  4 ,  Qingsong Liu  1  5
Affiliations
  • 1. High Magnetic Field Laboratory, Key Laboratory of High Magnetic Field and Ion Beam Physical Biology, Hefei Institutes of Physical Science , Chinese Academy of Sciences , Hefei 230031 , People's Republic of China.
  • 2. Institutes of Chronic Disease , Qingdao University , Qingdao 266003 , People's Republic of China.
  • 3. School of Medicine and Pharmacy , Ocean University of China , Qingdao 266003 , People's Republic of China.
  • 4. Department of Pharmaceutical Sciences, Daniel K. Inouye College of Pharmacy , University of Hawai'i at Hilo , Hilo , Hawaii 96720 , United States.
  • 5. Institute of Physical Science and Information Technology , Anhui University , Hefei 230601 , People's Republic of China.
PMID: 30994348 DOI: 10.1021/acs.jnatprod.9b00100
Abstract

Six new nardosinane-type sesquiterpenoids, clavukoellians A-F (1-6), together with one new neolemnane-type sesquiterpene, 4- O-deacetylparalemnolin D (7), were isolated from the marine soft coral Clavularia koellikeri. The structures of compounds 1-7 were elucidated by NMR spectroscopy, ECD analysis, and quantum chemical calculation methods. Compounds 1 and 7 demonstrated significant antiangiogenic activities in wound healing assays on HUVECs.

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