1. Others Protein Tyrosine Kinase/RTK
  2. Isotope-Labeled Compounds PDGFR VEGFR FGFR
  3. Nintedanib-d8

Nintedanib-d8 is deuterium labeled Nintedanib. Nintedanib (BIBF 1120) is a potent triple angiokinase inhibitor for VEGFR1/2/3, FGFR1/2/3 and PDGFRα/β with IC50s of 34 nM/13 nM/13 nM, 69 nM/37 nM/108 nM and 59 nM/65 nM, respectively.

For research use only. We do not sell to patients.

Nintedanib-d<sub>8</sub> Chemical Structure

Nintedanib-d8 Chemical Structure

CAS No. : 1624587-87-6

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Description

Nintedanib-d8 is deuterium labeled Nintedanib. Nintedanib (BIBF 1120) is a potent triple angiokinase inhibitor for VEGFR1/2/3, FGFR1/2/3 and PDGFRα/β with IC50s of 34 nM/13 nM/13 nM, 69 nM/37 nM/108 nM and 59 nM/65 nM, respectively.

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

547.67

Formula

C31H25D8N5O4

CAS No.
SMILES

CN(C([2H])([2H])C1([2H])[2H])C([2H])([2H])C([2H])([2H])N1CC(N(C)C(C=C2)=CC=C2N/C(C3=CC=CC=C3)=C4C5=CC=C(C(OC)=O)C=C5NC/4=O)=O

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent & Solubility
In Vitro: 

DMSO : 11.36 mg/mL (20.74 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8259 mL 9.1296 mL 18.2592 mL
5 mM 0.3652 mL 1.8259 mL 3.6518 mL
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Purity & Documentation
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Complete Stock Solution Preparation Table

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.8259 mL 9.1296 mL 18.2592 mL 45.6479 mL
5 mM 0.3652 mL 1.8259 mL 3.6518 mL 9.1296 mL
10 mM 0.1826 mL 0.9130 mL 1.8259 mL 4.5648 mL
15 mM 0.1217 mL 0.6086 mL 1.2173 mL 3.0432 mL
20 mM 0.0913 mL 0.4565 mL 0.9130 mL 2.2824 mL
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
Nintedanib-d8
Cat. No.:
HY-50904S2
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