1. Signaling Pathways
  2. Protein Tyrosine Kinase/RTK
  3. FGFR
  4. FGFR2 Inhibitors

FGFR2 Inhibitors

FGFR

FGFR1

FGFR2

FGFR3

FGFR4

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Sorry. There is currently no product that acts on isoform FGFR2 together.

Please try each isoform separately.

FGFR2 Specific Inhibitors
Product Name FGFR2 FGFR1 FGFR3 FGFR4 FGFR2 Selectivity Purity
FGFR2-IN-2
FGFR2, IC50: 29 nM
FGFR1, IC50: 389 nM
FGFR3, IC50: 758 nM
  Selective Inhibitor 98.09%
Formononetin
FGFR2, IC50: 4.31 μM
      Selective Inhibitor 99.88%
Alofanib
FGFR2
      Selective Inhibitor 98.81%
Nintedanib
FGFR2, IC50: 37 nM
FGFR1, IC50: 69 nM
FGFR3, IC50: 108 nM
  Pan Inhibitor 99.82%
Erdafitinib
FGFR2, IC50: 2.5 nM
FGFR1, IC50: 1.2 nM
FGFR3, IC50: 3.0 nM
FGFR4, IC50: 5.7 nM
Pan Inhibitor 99.66%
Surfen dihydrochloride
FGFR2, IC50: 5 μM
      Pan Inhibitor
Infigratinib
FGFR2, IC50: 1.4 nM
FGFR1, IC50: 0.9 nM
FGFR3, IC50: 1 nM
FGFR4, IC50: 60 nM
Pan Inhibitor 99.70%
Pemigatinib
FGFR2, IC50: 0.5 nM
FGFR1, IC50: 0.4 nM
FGFR3, IC50: 1.2 nM
FGFR4, IC50: 30 nM
Pan Inhibitor 99.88%
AZD4547
FGFR2, IC50: 2.5 nM
FGFR1, IC50: 0.2 nM
FGFR3, IC50: 1.8 nM
FGFR4, IC50: 165 nM
Pan Inhibitor 99.76%
Futibatinib
FGFR2, IC50: 1.3 nM
wild-type FGFR2, IC50: 0.3 nM
FGFR2 V5651, IC50: 1-3 nM
FGFR2 N550H, IC50: 3.6 nM
FGFR2 E566G, IC50: 2.4 nM
FGFR1, IC50: 3.9 nM
FGFR3, IC50: 1.6 nM
FGFR4, IC50: 8.3 nM
Pan Inhibitor 99.46%
Nintedanib esylate
FGFR2, IC50: 37 nM
FGFR1, IC50: 69 nM
FGFR3, IC50: 108 nM
  Pan Inhibitor 99.94%
Roblitinib
FGFR2, IC50: >10 μM
FGFR1, IC50: >10 μM
FGFR3, IC50: >10 μM
FGFR4, IC50: 1.9 nM
rat FGFR4, IC50: >10 μM
Pan Inhibitor 99.33%
Ferulic acid
FGFR2, IC50: 12.5 μM
FGFR1, IC50: 3.78 μM
    Pan Inhibitor 99.86%
BLU9931
FGFR2, IC50: 493 nM
FGFR1, IC50: 591 nM
FGFR3, IC50: 150 nM
FGFR4, IC50: 3 nM
Pan Inhibitor 99.95%
Gandotinib
FGFR2, IC50: 32 nM
 
FGFR3, IC50: 106 nM
  Pan Inhibitor 99.82%
LY2874455
FGFR2, IC50: 2.6 nM
FGFR1, IC50: 2.8 nM
FGFR3, IC50: 6.4 nM
FGFR4, IC50: 6 nM
Pan Inhibitor 98.06%
ENMD-2076
FGFR2, IC50: 70.8 nM
FGFR1, IC50: 92.7 nM
    Pan Inhibitor 99.12%
Zoligratinib
FGFR2, IC50: 7.6 nM
FGFR1, IC50: 9.3 nM
FGFR3, IC50: 22 nM
FGFR4, IC50: 290 nM
Pan Inhibitor 99.32%
Derazantinib
FGFR2, IC50: 1.8 nM
FGFR1, IC50: 4.5 nM
FGFR3, IC50: 4.5 nM
  Pan Inhibitor 99.18%
Lucitanib
FGFR2, IC50: 82.5 nM
FGFR1, IC50: 17.5 nM
    Pan Inhibitor 98.94%
PRN1371
FGFR2, IC50: 1.3 nM
FGFR1, IC50: 0.6 nM
FGFR3, IC50: 4.1 nM
FGFR4, IC50: 19.3 nM
Pan Inhibitor 99.72%
FIIN-2
FGFR2, IC50: 4.3 nM
FGFR1, IC50: 3.1 nM
FGFR3, IC50: 27 nM
FGFR4, IC50: 45 nM
Pan Inhibitor 99.63%
TG 100801
FGFR2, IC50: 16 nM
FGFR1, IC50: 2 nM
    Pan Inhibitor 98.03%
ODM-203
FGFR2, IC50: 16 nM
FGFR1, IC50: 11 nM
FGFR3, IC50: 6 nM
FGFR4, IC50: 35 nM
Pan Inhibitor 99.33%
S49076
FGFR2, IC50: 17 nM
FGFR2N549H, IC50: 19 nM
FGFR1, IC50: 18 nM
FGFR1V561M, IC50: 23 nM
FGFR3, IC50: 15 nM
  Pan Inhibitor 99.71%
ASP5878
FGFR2, IC50: 0.6 nM
FGFR1, IC50: 0.47 nM
FGFR3, IC50: 0.74 nM
FGFR4, IC50: 3.5 nM
Pan Inhibitor 99.86%
Infigratinib phosphate
FGFR2, IC50: 1.4 nM
FGFR1, IC50: 0.9 nM
FGFR3, IC50: 1 nM
FGFR4, IC50: 60 nM
Pan Inhibitor
FIIN-3
FGFR2, IC50: 21 nM
FGFR1, IC50: 13.1 nM
FGFR3, IC50: 31.4 nM
FGFR4, IC50: 35.3 nM
Pan Inhibitor 98.13%
ENMD-2076 Tartrate
FGFR2, IC50: 70.8 nM
FGFR1, IC50: 92.7 nM
    Pan Inhibitor 98.87%
CPL304110
FGFR2, IC50: 0.5 nM
FGFR1, IC50: 0.75 nM
FGFR3, IC50: 3.05 nM
  Pan Inhibitor 99.68%
TG 100572
FGFR2, IC50: 16 nM
FGFR1, IC50: 2 nM
    Pan Inhibitor
E7090
FGFR2, IC50: 0.50 nM
FGFR1, IC50: 0.71 nM
FGFR3, IC50: 1.2 nM
FGFR4, IC50: 120 nM
Pan Inhibitor
E7090 succinate
FGFR2, IC50: 0.50 nM
FGFR1, IC50: 0.71 nM
FGFR3, IC50: 1.2 nM
FGFR4, IC50: 120 nM
Pan Inhibitor
Aprutumab
FGFR2-IIIb
FGFR2-IIIc
      Pan Inhibitor
FGFR4-IN-5
FGFR2, IC50: 505 nM
   
FGFR4, IC50: 6.5 nM
Pan Inhibitor 98.06%
ARQ 069
unphosphorylated FGFR2, IC50: 1.23 μM
FGFR2 autophosphorylation, IC50: 1.9 μM
unphosphorylated FGFR1, IC50: 0.84 μM
FGFR1 autophosphorylation, IC50: 2.8 μM
    Pan Inhibitor
FGFR-IN-2
FGFR2, IC50: 4.3 nM
FGFR1, IC50: 7.3 nM
FGFR3, IC50: 7.6 nM
FGFR4, IC50: 11 nM
Pan Inhibitor
FIIN-1
FGFR2, Kd: 6.9 nM
FGFR2, IC50: 6.2 nM
FGFR1, Kd: 2.8 nM
FGFR1, IC50: 9.2 nM
FGFR3, Kd: 5.4 nM
FGFR3, IC50: 11.9 nM
FGFR4, Kd: 120 nM
FGFR4, IC50: 189 nM
Pan Inhibitor
3-Methylthienyl-carbonyl-JNJ-7706621
FGFR2, IC50: 0.22 μM
      Pan Inhibitor
FGFR3-IN-3
FGFR2, IC50: 3.1 nM
FGFR1, IC50: 2.1 nM
FGFR3, IC50: 4.3 nM
FGFR4, IC50: 74 nM
Pan Inhibitor
FGFR3-IN-1
FGFR2, IC50: 5.1 nM
FGFR1, IC50: 40 nM
FGFR3, IC50: 12 nM
  Pan Inhibitor
TG 100801 Hydrochloride
FGFR2, IC50: 16 nM
FGFR1, IC50: 2 nM
    Pan Inhibitor
Rogaratinib
FGFR2
FGFR1
FGFR3
FGFR4
Inhibitor 99.48%
Picrasidine Q
FGFR2
      Inhibitor