BR-cpd7
Based on 1 Customer Validation
BR-cpd7 is a PROTAC degrader for fibroblast growth factor receptor FGFR1/2 with DC50 of 10 nM. BR-cpd7 arrests cell cycle, inhibits proliferations of FGFR1/2 aberrant activated tumor cells.
(Pink: FGFR1 and FGFR2 ligand (HY-160013); Blue: Cereblon ligand (HY-131717); Black: linker).
For research use only. We do not sell to patients.
- Purity: 98.01%
- Formula: C44H47Cl2N11O8
- Molecular Weight:928.82
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Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
All PROTACs Isoforms
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Biological Activity
Chemical Information
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Appearance Solid
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Molecular Weight 928.82
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Formula C44H47Cl2N11O8
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Color Light yellow to yellow
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SMILES
COC1=CC(OC)=C(C(NC(N(C2=CC(NC3=CC=C(C=C3)N4CCN(CC4)C5CCN(CC5)C(CNC6=CC=CC7=C6C(N(C7=O)C8CCC(NC8=O)=O)=O)=O)=NC=N2)C)=O)=C1Cl)Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 100 mg/mL (107.66 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (265 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.0766 mL | 5.3832 mL | 10.7663 mL | 26.9159 mL |
| 5 mM | 0.2153 mL | 1.0766 mL | 2.1533 mL | 5.3832 mL | |
| 10 mM | 0.1077 mL | 0.5383 mL | 1.0766 mL | 2.6916 mL | |
| 15 mM | 0.0718 mL | 0.3589 mL | 0.7178 mL | 1.7944 mL | |
| 20 mM | 0.0538 mL | 0.2692 mL | 0.5383 mL | 1.3458 mL | |
| 25 mM | 0.0431 mL | 0.2153 mL | 0.4307 mL | 1.0766 mL | |
| 30 mM | 0.0359 mL | 0.1794 mL | 0.3589 mL | 0.8972 mL | |
| 40 mM | 0.0269 mL | 0.1346 mL | 0.2692 mL | 0.6729 mL | |
| 50 mM | 0.0215 mL | 0.1077 mL | 0.2153 mL | 0.5383 mL | |
| 60 mM | 0.0179 mL | 0.0897 mL | 0.1794 mL | 0.4486 mL | |
| 80 mM | 0.0135 mL | 0.0673 mL | 0.1346 mL | 0.3364 mL | |
| 100 mM | 0.0108 mL | 0.0538 mL | 0.1077 mL | 0.2692 mL |
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