1. PROTAC
  2. Ligand for E3 Ligase
  3. Thalidomide-NH-CH2-COOH

Thalidomide-NH-CH2-COOH 

Cat. No.: HY-131717 Purity: 98.20%
Handling Instructions

Thalidomide-NH-CH2-COOH is the Thalidomide-based cereblon ligand used in the recruitment of CRBN protein. Thalidomide-NH-CH2-COOH can be connected to the ligand for protein by a linker to form PROTACs, such as THAL-SNS-032 (HY-123937).

For research use only. We do not sell to patients.

Thalidomide-NH-CH2-COOH Chemical Structure

Thalidomide-NH-CH2-COOH Chemical Structure

CAS No. : 927670-97-1

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Description

Thalidomide-NH-CH2-COOH is the Thalidomide-based cereblon ligand used in the recruitment of CRBN protein. Thalidomide-NH-CH2-COOH can be connected to the ligand for protein by a linker to form PROTACs, such as THAL-SNS-032 (HY-123937)[1].

IC50 & Target[1]

Cereblon

 

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

331.28

Formula

C₁₅H₁₃N₃O₆

CAS No.

927670-97-1

SMILES

O=C(O)CNC1=CC=CC(C(N2C(CC3)C(NC3=O)=O)=O)=C1C2=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
References
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Keywords:

Thalidomide-NH-CH2-COOHLigand for E3 LigaseE3 ligase-recruiting MoietyCRBNcereblonThalidomideInhibitorinhibitorinhibit

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Product Name:
Thalidomide-NH-CH2-COOH
Cat. No.:
HY-131717
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