2. PROTAC Cell Cycle/DNA Damage
  3. PROTACs CDK
  4. THAL-SNS-032

THAL-SNS-032 is a selective CDK9 degrader PROTAC consisting of a CDK-binding SNS-032 ligand linked to a thalidomide derivative that binds the E3 ubiquitin ligase Cereblon (CRBN).

For research use only. We do not sell to patients.

CAS No. : 2139287-33-3

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Customer Review

Based on 10 publication(s) in Google Scholar

THAL-SNS-032 Related Antibodies

Top Publications Citing Use of Products

    THAL-SNS-032 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2024 Dec 5;15(1):10594.  [Abstract]

    MOLT-4 and HH cells were treated with THAL-SNS-032 ( and western blots were conducted.

    THAL-SNS-032 purchased from MedChemExpress. Usage Cited in: J Med Chem. 2025 Oct 23;68(20):21172-21186.  [Abstract]

    Changes in tumor volume during dCDK9-202, (SNS032), or THAL-SNS032) treatments (10 mg/kg, i.v., qod).

    View All PROTACs Isoform Specific Products:

    View All Isoforms
    von Hippel-Lindau (VHL) Cereblon MDM2 cIAP1

    View All CDK Isoform Specific Products:

    View All Isoforms
    CDK1 CDK2 CDK3 CDK4 CDK5 CDK6 CDK7 CDK8 CDK9 CDK11 CDK12 CDK13 CDK14 CDK16 CDK19 CDC CLK Pho85 CDK10 CDK15 CDK17 CDK18 CDK20 PITSLRE

    • Biological Activity

    • Purity & Documentation

    • References

    • Customer Review

    Description

    THAL-SNS-032 is a selective CDK9 degrader PROTAC consisting of a CDK-binding SNS-032 ligand linked to a thalidomide derivative that binds the E3 ubiquitin ligase Cereblon (CRBN)[1].

    IC50 & Target

    CDK9[1]
    Cellular Effect
    Cell Line Type Value Description References
    CWR22R IC50
    0.049 μM
    Compound: THAL-SNS032
    Antiproliferative activity against human 22Rv1 cells assessed as reduction in cell viability measured after 5 days by CellTiter-Glo assay
    Antiproliferative activity against human 22Rv1 cells assessed as reduction in cell viability measured after 5 days by CellTiter-Glo assay
    		[PMID: 35925880]
    MOLT-4 IC50
    50 nM
    Compound: 80
    Antiproliferative activity against human MOLT4 cells incubated for 72 hrs by cell titer glo assay
    Antiproliferative activity against human MOLT4 cells incubated for 72 hrs by cell titer glo assay
    		[PMID: 32866383]
    MOLT-4 IC50
    50 nM
    Compound: 87; THAL-SNS-032
    Antiproliferative activity against human MOLT-4 cells assessed as inhibition of cell proliferation
    Antiproliferative activity against human MOLT-4 cells assessed as inhibition of cell proliferation
    		[PMID: 32707525]
    U2932 IC50
    306 nM
    Compound: THAL-SNS-032
    Cytotoxicity against human U2932 cells assessed as inhibition of cell growth measured after 72 hrs by CCK-8 assay
    Cytotoxicity against human U2932 cells assessed as inhibition of cell growth measured after 72 hrs by CCK-8 assay
    		[PMID: 37671907]
    In Vitro

    THAL-SNS-032 selectively induces degradation of CDK9[1].
    THAL-SNS-032 diminishes elongating polymerase II[1].
    THAL-SNS-032 inhibits proliferation of MOLT4 cells with an IC50 of 50 nM[1].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    THAL-SNS-032 Related Antibodies
    Molecular Weight

    869.02

    Formula

    C40H52N8O10S2
    CAS No.
    Appearance

    Solid

    Color

    Light yellow to yellow

    SMILES

    O=C(NCCOCCOCCOCCNC1=CC=CC(C(N2C(CC3)C(NC3=O)=O)=O)=C1C2=O)CN4CCC(C(NC5=NC=C(SCC6=NC=C(C(C)(C)C)O6)S5)=O)CC4
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    -20°C, stored under nitrogen

    *In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

    Solvent & Solubility
    In Vitro: 

    DMSO : 100 mg/mL (115.07 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 1.1507 mL 5.7536 mL 11.5072 mL
    5 mM 0.2301 mL 1.1507 mL 2.3014 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    • Molarity Calculator

    • Dilution Calculator

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    Mass
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    Concentration
    ×
    Volume
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    Molecular Weight *

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start)

    C1

    ×
    Volume (start)

    V1

    =
    Concentration (final)

    C2

    ×
    Volume (final)

    V2

    In Vivo:

    Select the appropriate dissolution method based on your experimental animal and administration route.

    For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
    To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

      Solubility: ≥ 2.5 mg/mL (2.88 mM); Clear solution

      This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

      Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

      Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
    • Protocol 2

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

      Solubility: ≥ 2.5 mg/mL (2.88 mM); Clear solution

      This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

      Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

      Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

    Dosage

    mg/kg

    Animal weight
    (per animal)

    g

    Dosing volume
    (per animal)

    μL

    Number of animals

    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Please enter your animal formula composition:
    %
    DMSO +
    % 
    +
    %
    Tween-80 +
    %
    Saline
    Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
    The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
    Calculation results:
    Working solution concentration: mg/mL
    Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).

    *In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
    Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
     If the continuous dosing period exceeds half a month, please choose this protocol carefully.
    Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
    Purity & Documentation
    References

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    DMSO 1 mM 1.1507 mL 5.7536 mL 11.5072 mL 28.7680 mL
    5 mM 0.2301 mL 1.1507 mL 2.3014 mL 5.7536 mL
    10 mM 0.1151 mL 0.5754 mL 1.1507 mL 2.8768 mL
    15 mM 0.0767 mL 0.3836 mL 0.7671 mL 1.9179 mL
    20 mM 0.0575 mL 0.2877 mL 0.5754 mL 1.4384 mL
    25 mM 0.0460 mL 0.2301 mL 0.4603 mL 1.1507 mL
    30 mM 0.0384 mL 0.1918 mL 0.3836 mL 0.9589 mL
    40 mM 0.0288 mL 0.1438 mL 0.2877 mL 0.7192 mL
    50 mM 0.0230 mL 0.1151 mL 0.2301 mL 0.5754 mL
    60 mM 0.0192 mL 0.0959 mL 0.1918 mL 0.4795 mL
    80 mM 0.0144 mL 0.0719 mL 0.1438 mL 0.3596 mL
    100 mM 0.0115 mL 0.0575 mL 0.1151 mL 0.2877 mL
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    THAL-SNS-032 Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    THAL-SNS-0322139287-33-3PROTACsCDKCyclin dependent kinaseInhibitorinhibitorinhibit

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