1. PROTAC
    Cell Cycle/DNA Damage
  2. PROTAC
    CDK
  3. THAL-SNS-032

THAL-SNS-032 

Cat. No.: HY-123937 Purity: 99.16%
Handling Instructions

THAL-SNS-032 is a selective CDK9 degrader PROTAC consisting of a CDK-binding SNS-032 ligand linked to a thalidomide derivative that binds the E3 ubiquitin ligase Cereblon (CRBN).

For research use only. We do not sell to patients.

THAL-SNS-032 Chemical Structure

THAL-SNS-032 Chemical Structure

CAS No. : 2139287-33-3

Size Price Stock Quantity
5 mg USD 350 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

THAL-SNS-032 is a selective CDK9 degrader PROTAC consisting of a CDK-binding SNS-032 ligand linked to a thalidomide derivative that binds the E3 ubiquitin ligase Cereblon (CRBN)[1].

IC50 & Target

CDK9[1]

In Vitro

THAL-SNS-032 selectively induces degradation of CDK9[1].
THAL-SNS-032 diminishes elongating polymerase II[1].
THAL-SNS-032 inhibits proliferation of MOLT4 cells with an IC50 of 50 nM[1].

Molecular Weight

869.02

Formula

C₄₀H₅₂N₈O₁₀S₂

CAS No.

2139287-33-3

SMILES

O=C(NCCOCCOCCOCCNC1=CC=CC(C(N2C(CC3)C(NC3=O)=O)=O)=C1C2=O)CN4CCC(C(NC5=NC=C(SCC6=NC=C(C(C)(C)C)O6)S5)=O)CC4

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (115.07 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.1507 mL 5.7536 mL 11.5072 mL
5 mM 0.2301 mL 1.1507 mL 2.3014 mL
10 mM 0.1151 mL 0.5754 mL 1.1507 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (2.88 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (2.88 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: 99.16%

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Keywords:

THAL-SNS-032PROTACCDKProteolysis-targeting chimeraCyclin dependent kinaseInhibitorinhibitorinhibit

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Product name:
THAL-SNS-032
Cat. No.:
HY-123937
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