1. Signaling Pathways
  2. Protein Tyrosine Kinase/RTK
  3. FGFR
  4. FGFR4 Inhibitors

FGFR4 Inhibitors

FGFR

FGFR1

FGFR2

FGFR3

FGFR4

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Sorry. There is currently no product that acts on isoform FGFR4 together.

Please try each isoform separately.

FGFR4 Specific Inhibitors
Product Name FGFR4 FGFR1 FGFR2 FGFR3 FGFR4 Selectivity Purity
FGFR4-IN-5
FGFR4, IC50: 6.5 nM
 
FGFR2, IC50: 505 nM
  Selective Inhibitor 98.06%
Fisogatinib
FGFR4, IC50: 5 nM
      Selective Inhibitor 99.87%
Roblitinib
FGFR4, IC50: 1.9 nM
rat FGFR4, IC50: >10 μM
FGFR1, IC50: >10 μM
FGFR2, IC50: >10 μM
FGFR3, IC50: >10 μM
Selective Inhibitor ≥98.0%
BLU9931
FGFR4, IC50: 3 nM
FGFR1, IC50: 591 nM
FGFR2, IC50: 493 nM
FGFR3, IC50: 150 nM
Selective Inhibitor ≥98.0%
FGFR4-IN-1
FGFR4, IC50: 0.7 nM
      Selective Inhibitor 99.88%
FGFR4-IN-4
FGFR4
      Selective Inhibitor
Erdafitinib
FGFR4, IC50: 5.7 nM
FGFR1, IC50: 1.2 nM
FGFR2, IC50: 2.5 nM
FGFR3, IC50: 3.0 nM
Pan Inhibitor 99.66%
Infigratinib
FGFR4, IC50: 60 nM
FGFR1, IC50: 0.9 nM
FGFR2, IC50: 1.4 nM
FGFR3, IC50: 1 nM
Pan Inhibitor 99.55%
E7090
FGFR4, IC50: 120 nM
FGFR1, IC50: 0.71 nM
FGFR2, IC50: 0.50 nM
FGFR3, IC50: 1.2 nM
Pan Inhibitor
Pemigatinib
FGFR4, IC50: 30 nM
FGFR1, IC50: 0.4 nM
FGFR2, IC50: 0.5 nM
FGFR3, IC50: 1.2 nM
Pan Inhibitor 99.88%
AZD4547
FGFR4, IC50: 165 nM
FGFR1, IC50: 0.2 nM
FGFR2, IC50: 2.5 nM
FGFR3, IC50: 1.8 nM
Pan Inhibitor 99.76%
Futibatinib
FGFR4, IC50: 8.3 nM
FGFR1, IC50: 3.9 nM
FGFR2, IC50: 1.3 nM
wild-type FGFR2, IC50: 0.3 nM
FGFR2 V5651, IC50: 1-3 nM
FGFR2 N550H, IC50: 3.6 nM
FGFR2 E566G, IC50: 2.4 nM
FGFR3, IC50: 1.6 nM
Pan Inhibitor 98.80%
LY2874455
FGFR4, IC50: 6 nM
FGFR1, IC50: 2.8 nM
FGFR2, IC50: 2.6 nM
FGFR3, IC50: 6.4 nM
Pan Inhibitor 98.06%
Zoligratinib
FGFR4, IC50: 290 nM
FGFR1, IC50: 9.3 nM
FGFR2, IC50: 7.6 nM
FGFR3, IC50: 22 nM
Pan Inhibitor 99.73%
PRN1371
FGFR4, IC50: 19.3 nM
FGFR1, IC50: 0.6 nM
FGFR2, IC50: 1.3 nM
FGFR3, IC50: 4.1 nM
Pan Inhibitor 99.72%
ODM-203
FGFR4, IC50: 35 nM
FGFR1, IC50: 11 nM
FGFR2, IC50: 16 nM
FGFR3, IC50: 6 nM
Pan Inhibitor 99.33%
FIIN-2
FGFR4, IC50: 45 nM
FGFR1, IC50: 3.1 nM
FGFR2, IC50: 4.3 nM
FGFR3, IC50: 27 nM
Pan Inhibitor 99.63%
FIIN-3
FGFR4, IC50: 35.3 nM
FGFR1, IC50: 13.1 nM
FGFR2, IC50: 21 nM
FGFR3, IC50: 31.4 nM
Pan Inhibitor 98.13%
ASP5878
FGFR4, IC50: 3.5 nM
FGFR1, IC50: 0.47 nM
FGFR2, IC50: 0.6 nM
FGFR3, IC50: 0.74 nM
Pan Inhibitor 99.71%
Infigratinib phosphate
FGFR4, IC50: 60 nM
FGFR1, IC50: 0.9 nM
FGFR2, IC50: 1.4 nM
FGFR3, IC50: 1 nM
Pan Inhibitor 97.74%
E7090 succinate
FGFR4, IC50: 120 nM
FGFR1, IC50: 0.71 nM
FGFR2, IC50: 0.50 nM
FGFR3, IC50: 1.2 nM
Pan Inhibitor
FIIN-1
FGFR4, Kd: 120 nM
FGFR4, IC50: 189 nM
FGFR1, Kd: 2.8 nM
FGFR1, IC50: 9.2 nM
FGFR2, Kd: 6.9 nM
FGFR2, IC50: 6.2 nM
FGFR3, Kd: 5.4 nM
FGFR3, IC50: 11.9 nM
Pan Inhibitor
Rogaratinib
FGFR4
FGFR1
FGFR2
FGFR3
Inhibitor 99.86%