FGF-19, a novel fibroblast growth factor with unique specificity for FGFR4

  • Cytokine. 1999 Oct;11(10):729-35. doi: 10.1006/cyto.1999.0485.
M H Xie  1 ,  I Holcomb ,  B Deuel ,  P Dowd ,  A Huang ,  A Vagts ,  J Foster ,  J Liang ,  J Brush ,  Q Gu ,  K Hillan ,  A Goddard ,  A L Gurney
Affiliations
  • 1. Department of Molecular Biology, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
PMID: 10525310 DOI: 10.1006/cyto.1999.0485
Abstract

We have identified a novel Fibroblast Growth Factor, FGF-19, the most distant member of the FGF Family described to date. FGF-19 is a high affinity, heparin dependent ligand for FGFR4 and is the first member of the FGF Family to show exclusive binding to FGFR4. Human FGF-19 maps to chromosome 11 q13.1, a region associated with an osteoporosis-pseudoglioma syndrome of skeletal and retinal defects. FGF-19 message is expressed in several tissues including fetal cartilage, skin, and retina, as well as adult gall bladder and is overexpressed in a colon adenocarcinoma cell line.