FGF-19
FGF-19 is a hormone-like FGF that pairs obligatorily with the co-receptor β-klotho to activate FGFR4 in liver. Secreted by ileal enterocytes after bile acid absorption, it feeds back to suppress CYP7A1 and bile acid synthesis, and it also regulates hepatic glucose and lipid metabolism and protein synthesis. FGF19 lies within the 11q13 amplicon and is overexpressed in a subset of hepatocellular carcinomas, driving tumor growth through autocrine FGFR4 signaling; anti-FGF19 antibodies and FGFR4 inhibitors are in clinical development. Recombinant FGF-19 is used for FGFR4/β-klotho signaling assays, metabolic research and oncology target validation.
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FGF-19 Recombinant Proteins (5)
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Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
