2. Protein Tyrosine Kinase/RTK
  3. FGFR
  4. EphB1-IN-2

EphB1-IN-2 is a mutant-selective kinase inhibitor of ABL and FGFR4, with an IC50 of 14 nM against ABLG321C mutant and 163 nM against FGFR4G556C mutant. EphB1-IN-2 shows selectively over wild-type ABL and FGFR4.

For research use only. We do not sell to patients.

EphB1-IN-2

EphB1-IN-2 Chemical Structure

CAS No. : 2097512-73-5

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EphB1-IN-2 Related Antibodies

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Description

EphB1-IN-2 is a mutant-selective kinase inhibitor of ABL and FGFR4, with an IC50 of 14 nM against ABLG321C mutant and 163 nM against FGFR4G556C mutant. EphB1-IN-2 shows selectively over wild-type ABL and FGFR4[1][2].

IC50 & Target[2]

FGFR4

>10000 nM (IC50)

In Vitro

EphB1-IN-2 (compound 10) shows 37-fold selective inhibition of ABLG321C over wild-type ABL, with IC50 values of 14 nM and 530 nM, respectively[2].
EphB1-IN-2 shows greater than 61-fold selective inhibition of FGFR4G556C over wild-type FGFR4, with an IC50 of 163 nM against FGFR4G556C and an IC50 greater than 10,000 nM against wild-type FGFR4[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

EphB1-IN-2 Related Antibodies
Molecular Weight

342.78

Formula

C17H15ClN4O2
CAS No.
SMILES

O=C(CCl)NC1=CC2=NC=NC(NC3=CC(OC)=CC=C3)=C2C=C1
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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EphB1-IN-2 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

EphB1-IN-22097512-73-5FGFRFibroblast growth factor receptorFGFR4 (G556C mutant)wild-type ABLkinase inhibitorwild-type FGFR4ABL (G321C mutant)Inhibitorinhibitorinhibit

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HY-183909
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