FGF/FGFR signaling in health and disease

  • Signal Transduct Target Ther. 2020 Sep 2;5(1):181. doi: 10.1038/s41392-020-00222-7.
Yangli Xie  #  1 ,  Nan Su  #  2 ,  Jing Yang  2 ,  Qiaoyan Tan  2 ,  Shuo Huang  2 ,  Min Jin  2 ,  Zhenhong Ni  2 ,  Bin Zhang  2 ,  Dali Zhang  2 ,  Fengtao Luo  2 ,  Hangang Chen  2 ,  Xianding Sun  2 ,  Jian Q Feng  3 ,  Huabing Qi  4 ,  Lin Chen  5
Affiliations
  • 1. Department of Wound Repair and Rehabilitation Medicine, State Key Laboratory of Trauma, Burns and Combined Injury, Trauma Center, Research Institute of Surgery, Daping Hospital, Army Medical University, Chongqing, China. [email protected].
  • 2. Department of Wound Repair and Rehabilitation Medicine, State Key Laboratory of Trauma, Burns and Combined Injury, Trauma Center, Research Institute of Surgery, Daping Hospital, Army Medical University, Chongqing, China.
  • 3. Department of Biomedical Sciences, Texas A&M University College of Dentistry, Dallas, TX, 75246, USA.
  • 4. Department of Wound Repair and Rehabilitation Medicine, State Key Laboratory of Trauma, Burns and Combined Injury, Trauma Center, Research Institute of Surgery, Daping Hospital, Army Medical University, Chongqing, China. [email protected].
  • 5. Department of Wound Repair and Rehabilitation Medicine, State Key Laboratory of Trauma, Burns and Combined Injury, Trauma Center, Research Institute of Surgery, Daping Hospital, Army Medical University, Chongqing, China. [email protected].
  • # Contributed equally.
PMID: 32879300 DOI: 10.1038/s41392-020-00222-7
Abstract

Growing evidences suggest that the Fibroblast Growth Factor/FGF receptor (FGF/FGFR) signaling has crucial roles in a multitude of processes during embryonic development and adult homeostasis by regulating cellular lineage commitment, differentiation, proliferation, and Apoptosis of various types of cells. In this review, we provide a comprehensive overview of the current understanding of FGF signaling and its roles in organ development, injury repair, and the pathophysiology of spectrum of diseases, which is a consequence of FGF signaling dysregulation, including cancers and chronic kidney disease (CKD). In this context, the agonists and antagonists for FGF-FGFRs might have therapeutic benefits in multiple systems.