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Lenvatinib

(Synonyms: E7080)
95 Cited Publications
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Based on 95 publication(s) in Google Scholar

Lenvatinib (E7080) is an oral, multi-targeted tyrosine kinase inhibitor that inhibits VEGFR1-3, FGFR1-4, PDGFR, KIT, and RET, shows potent antitumor activities.

For research use only. We do not sell to patients.

  • Purity: 99.75%
  • CAS No.: 417716-92-8
  • Formula: C21H19ClN4O4
  • Molecular Weight:426.85
  • Storage:
    Powder   -20°C, 3 years , 4°C, 2 years ; In solvent   -80°C, 2 years , -20°C, 1 year
  • Lenvatinib Chemical Structure
    Lenvatinib Chemical Structure
  • Experimental Validation Results for Lenvatinib
  • Experimental Validation Results for Lenvatinib
  • Experimental Validation Results for Lenvatinib
  • Experimental Validation Results for Lenvatinib
  • Experimental Validation Results for Lenvatinib
  • Experimental Validation Results for Lenvatinib
  • Experimental Validation Results for Lenvatinib
CAS No.: 417716-92-8
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Find Your Local Distributor Your local distributor: Hycultec GmbHHycultec
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  • Lenvatinib Chemical Structure
    Lenvatinib Chemical Structure
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    Lenvatinib purchased from MedChemExpress. Usage Cited in: J Transl Med. 2022 Mar 7;20(1):116. [Abstract]

    Customer Validation
     H&E examination of vehicle and Lenvatinib (10 mg/kg daily by oral gavage)-treated tumors revealed markedly increase tumor necrosis and desmoplasia in the Lenvatinib-treated samples.

  • 1/16

    Lenvatinib purchased from MedChemExpress. Usage Cited in: J Oncol. 2022 Oct 18;2022:4537343. [Abstract]

    Customer Validation
     HepG2 and HepG2/R cells are treated with indicated doses of Lenvatinib for 24 h, and cellular viabilities are measured.

  • 1/16

    Lenvatinib purchased from MedChemExpress. Usage Cited in: J Oncol. 2022 Oct 18;2022:4537343. [Abstract]

    Customer Validation
     HepG2 and HepG2/R cells are treated with or without Lenvatinib (20 μM) for 24 h, and indicated proteins are measured by western blots.

  • 1/16

    Lenvatinib purchased from MedChemExpress. Usage Cited in: Cell Death Discov. 2021 Nov 18;7(1):359. [Abstract]

    Customer Validation
     Lenvatinib (1000 nM) has demonstrated the ability to significantly inhibit cell proliferation, and knockout of NF1 and DUSP9 significantly blocks the ability of lenvatinib to inhibit cell proliferation as well as the effect on cell number. ​

  • 1/16

    Lenvatinib purchased from MedChemExpress. Usage Cited in: J Cell Mol Med. 2021 Jan;25(1):549-560. [Abstract]

    Customer Validation
     The cell viability is measured by CCK-8 assay at different time intervals (24, 48, 72 and 96 h) when cells are cultured with 5 μM Lenvatinib.

  • 1/16

    Lenvatinib purchased from MedChemExpress. Usage Cited in: J Cell Mol Med. 2021 Jan;25(1):549-560. [Abstract]

    Customer Validation
     The mRNA expression of VEGFR2 in HepG2-WT/Lenvatinib (LR; 5 μM) and Huh7-WT/LR cells. VEGFR2 mRNA expression is up-regulated in HepG2-LR and Huh7LR cells.

  • 1/16

    Lenvatinib purchased from MedChemExpress. Usage Cited in: J Cell Mol Med. 2021 Jan;25(1):549-560. [Abstract]

    Customer Validation
     The protein expression of VEGFR2 in HepG2-WT/Lenvatinib (LR; 5 μM) and Huh7-WT/LR cells. Western blotting results show the downstream target RAS/MEK/ERK axis of VEGFR2 are obviously up‐regulated in HepG2-LR and Huh7-LR cells compared with their parental cells.

  • Lenvatinib