1. Protein Tyrosine Kinase/RTK
  2. PDGFR
  3. Seralutinib

Seralutinib (Synonyms: GB002; PK10571)

Cat. No.: HY-109190
Handling Instructions

Seralutinib (GB002) is an inhaled Pdgfr kinase inhibitor. Seralutinib (GB002) is used in the study for pulmonary arterial hypertension.

For research use only. We do not sell to patients.

Seralutinib Chemical Structure

Seralutinib Chemical Structure

CAS No. : 1619931-27-9

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Description

Seralutinib (GB002) is an inhaled Pdgfr kinase inhibitor. Seralutinib (GB002) is used in the study for pulmonary arterial hypertension[1].

In Vivo

Seralutinib (GB002) (two-week treatment, delivered by inhalation, in rats) significantly reduces right ventricular systolic pressure (Control PAH 85.2 ± 11 mmHg (n=7) vs GB002 46.7±3.9 mmHg (n=9), p<0.005) and mean pulmonary artery pressure (Control PAH 50.4 ± 5.4 mmHg (n=7) vs GB002 31.9±2.6 mmHg (n=9), p<0.005). Hemodynamic changes were accompanied by reduced pulmonary arteriole muscularization and restoration of BMPR2 protein expression in the lung lobes in Seralutinib (GB002)-treated animals. In parallel, decreased plasma levels of NT-proBNP and PDGF-B were observed, along with modulation of pro-inflammatory cytokines. Seralutinib (GB002) is well tolerated[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

469.53

Formula

C₂₇H₂₇N₅O₃

CAS No.

1619931-27-9

SMILES

O=C(C1=CC(C)=CN=C1)NC2=CC=CC([[email protected]@H](NC3=NC(C4=CC=C(OC)C(OC)=C4)=CN=C3)C)=C2

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

SeralutinibGB002 PK10571GB 002GB-002PK10571PK 10571PK-10571PDGFRPlatelet-derived growth factor receptorPulmonaryarterialhypertensionPAHInhibitorinhibitorinhibit

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Seralutinib
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