1. Protein Tyrosine Kinase/RTK
  2. c-Kit
    PDGFR

Ripretinib (Synonyms: DCC-2618)

Cat. No.: HY-112306 Purity: 99.46%
Handling Instructions

Ripretinib (DCC-2618) is a pan-KIT and PDGFRA inhibitor, and has antitumor activity.

For research use only. We do not sell to patients.

Ripretinib Chemical Structure

Ripretinib Chemical Structure

CAS No. : 1442472-39-0

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 236 In-stock
Estimated Time of Arrival: December 31
5 mg USD 210 In-stock
Estimated Time of Arrival: December 31
10 mg USD 310 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1100 In-stock
Estimated Time of Arrival: December 31
100 mg USD 1850 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

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  • Biological Activity

  • Technical Information

  • Purity & Documentation

  • References

Description

Ripretinib (DCC-2618) is a pan-KIT and PDGFRA inhibitor, and has antitumor activity.

IC50 & Target

PDGFRA

 

KIT

 

In Vitro

Ripretinib is a pan-KIT and PDGFRA inhibitor, shows cytotoxic activity against gastrointestinal stromal tumors[1]. Ripretinib suppresses phosphorylation of KIT and decreases the expression of phosphosphorylated (p)STAT5, pAKT and pERK1/2 in neoplastic mast cells. Ripretinib inhibits the growth of ROSAKIT K509I cells with an IC50 of 34 ± 10 nM, and also induces apoptosis in these cells. Ripretinib (0.1-1.0 μM) inhibits IgE-dependent histamine release from basophils and spontaneous tryptase release from neoplastic mast cells, and also counteracts growth and survival of leukemic monocytes and blast cells at 0.01-5 μM[2].

Clinical Trial
Solvent & Solubility
In Vitro: 

DMSO : ≥ 62.5 mg/mL (122.46 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9594 mL 9.7970 mL 19.5940 mL
5 mM 0.3919 mL 1.9594 mL 3.9188 mL
10 mM 0.1959 mL 0.9797 mL 1.9594 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (4.08 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (4.08 mM); Clear solution

References
Molecular Weight

510.36

Formula

C₂₄H₂₁BrFN₅O₂

CAS No.

1442472-39-0

SMILES

O=C(NC1=CC(C2=CC3=C(C=C(NC)N=C3)N(CC)C2=O)=C(Br)C=C1F)NC4=CC=CC=C4

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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Product Name:
Ripretinib
Cat. No.:
HY-112306
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Ripretinib

Cat. No.: HY-112306