Ripretinib (Standard)
Ripretinib (Standard) is the analytical standard of Ripretinib. This product is intended for research and analytical applications. Ripretinib (DCC-2618) is an orally bioavailable, selective KIT and PDGFRA switch-control inhibitor. Ripretinib (DCC-2618) targets and binds to both wild-type and mutant forms of KIT and PDGFRA specifically at their switch pocket binding sites, thereby preventing the switch from inactive to active conformations of these kinases and inactivating their wild-type and mutant forms. Ripretinib (DCC-2618) also inhibits multiple other kinase targets, such as FLT3 and KDR (or VEGFR-2). DCC-2618 exerts antineoplastic effect and induces apoptosis.
Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.
- Pureté : 98%
- CAS No.: 1442472-39-0
- Formule: C24H21BrFN5O2
- Masse moléculaire:510.36
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Product Information
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Chemical Information
- Pureté et documentation
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Help & FAQs
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HY-112306
RipretinibKIT/PDGFRA Inhibitor -
HY-15463
ImatinibTyrosine Kinases Inhibitor -
HY-13016
CabozantinibVEGFR2/MET Inhibitor -
HY-10206
AmuvatinibRTK Inhibitor -
HY-10331
RegorafenibMulti-kinase Inhibitor -
HY-101561
AvapritinibKIT/PDGFRA Inhibitor -
HY-15463R
Imatinib (Standard)Tyrosine Kinases Inhibitor -
HY-10209
Masitinibc-Kit Inhibitor -
HY-10201
SorafenibMultikinase Inhibitor -
HY-10209A
Masitinib mesylatec-Kit Inhibitor -
HY-11106
Nintedanib esylatePDGFR/VEGFR/FGFR Inhibitor -
HY-13016R
Cabozantinib (Standard)VEGFR2/MET Inhibitor
Product Information
Information
Application
The compound is the grade of analytical standard, which is the reference standard supplied assay. It is commonly used in qualitative, quantitative and methodological research experiments in HPLC, GC and MS.
Chemical Information
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CAS No. 1442472-39-0
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Masse moléculaire 510.36
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Formule C24H21BrFN5O2
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SMILES
O=C(NC1=CC(C2=CC3=C(C=C(NC)N=C3)N(CC)C2=O)=C(Br)C=C1F)NC4=CC=CC=C4
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Synonyms
DCC-2618 (Standard)
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
[1]. KIT/PDGFR Inhibitor DCC-2618.
[2]. BLU-285, DCC-2618 Show Activity against GIST. Cancer Discov. 2017 Feb;7(2):121-122. [Content Brief]
[3]. Schneeweiss M, et al. The KIT and PDGFRA switch-control inhibitor DCC-2618 blocks growth and survival of multiple neoplastic cell types in advanced mastocytosis. Haematologica. 2018 May;103(5):799-809. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Ripretinib (Standard) Related Classifications
HY-112306R Related Classifications
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