2. Protein Tyrosine Kinase/RTK Anti-infection
  3. PDGFR Parasite
  4. GSK190937

GSK190937 is a type II platelet-derived growth factor receptor alpha (PDGFRA) human kinase inhibitor with antimalarial activity. GSK190937 can inhibit the formation of hemozoin in the malaria parasite, resulting in the accumulation of free hemoglobin within the malaria parasite. GSK190937 shows IC50 values of 0.22, 0.59 and 0.25 μM against P. falciparum NF54, K1 and Dd2 parasite. GSK190937 shows an IC50 of 25 μM for CHO cells. GSK190937 can be used for research of malaria.

For research use only. We do not sell to patients.

GSK190937

GSK190937 Chemical Structure

CAS No. : 2651234-01-2

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GSK190937 Related Antibodies

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Description

GSK190937 is a type II platelet-derived growth factor receptor alpha (PDGFRA) human kinase inhibitor with antimalarial activity. GSK190937 can inhibit the formation of hemozoin in the malaria parasite, resulting in the accumulation of free hemoglobin within the malaria parasite. GSK190937 shows IC50 values of 0.22, 0.59 and 0.25 μM against P. falciparum NF54, K1 and Dd2 parasite. GSK190937 shows an IC50 of 25 μM for CHO cells. GSK190937 can be used for research of malaria[1].

IC50 & Target[1]

PDGFRα

 

Molecular Weight

427.33

Formula

C22H20Cl2N4O
CAS No.
SMILES

CC1=CN=C(N)C(/C=C/C2=CN=CC(C(NCCC3=C(Cl)C=C(Cl)C=C3)=O)=C2)=C1
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Room temperature in continental US; may vary elsewhere.
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Purity & Documentation
References
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GSK190937 Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

GSK1909372651234-01-2GSK 190937GSK-190937PDGFRParasitePlatelet-derived growth factor receptorInhibitorinhibitorinhibit

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