XRCC1 Antibody (YA1058)

製品番号: HY-P81314: データシート User Guide for Antibodies
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XRCC1 Antibody (YA1058) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to XRCC1.

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研究用途以外に使用した場合、当社は一切の責任を負いかねます。

容量	価格（税別）	在庫状況	数量
20 μL	$146	Get quote 2 - 3 Weeks 1 - 2 Weeks 3 - 4 Weeks 2 - 3 weeks	Estimated Time of Arrival: December 31
50 μL	$222	Get quote 2 - 3 Weeks 1 - 2 Weeks 3 - 4 Weeks 2 - 3 weeks	Estimated Time of Arrival: December 31
100 μL	$360	Get quote 2 - 3 Weeks 1 - 2 Weeks 3 - 4 Weeks 2 - 3 weeks	Estimated Time of Arrival: December 31
250 μL		お問い合わせ

Synthetic products have potential research and development risk.

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* アイテムを追加する前、数量をご選択ください

おすすめ:

WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
説明

製品説明

XRCC1 Antibody (YA1058) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to XRCC1.

Host

Mouse

Clonality

Monoclonal

分子量

Predicted band size: 69 kDa;

Observed band size: 82 kDa

Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.

Species Reactivity

Human

SwissProt ID

P18887

Gene ID

7515 [NCBI]

Immunogen

Purified recombinant human XRCC1 protein fragments expressed in E.coli.

Application &
Dilution Ratio

Application	Dilution Ratio
WB WB: Western Blot	1:500-1:1000

Sensitivity	Endogenous	純度	Affinity Purified
Conjugation	Non-conjugated	Modification	Unmodified
Isotype	IgG1

Appearance

Liquid

Formulation

Supplied in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

輸送条件

Shipping with blue ice.

Background

Function：Scaffold protein involved in DNA single-strand break repair by mediating the assembly of DNA break repair protein complexes (PubMed:11163244, PubMed:28002403). Negatively regulates ADP-ribosyltransferase activity of PARP1 during base-excision repair in order to prevent excessive PARP1 activity (PubMed:28002403, PubMed:34102106, PubMed:34811483). Recognizes and binds poly-ADP-ribose chains: specifically binds auto-poly-ADP-ribosylated PARP1, limiting its activity (PubMed:14500814, PubMed:34102106, PubMed:34811483)

Subcellular Localization：Nucleus; Chromosome

Expression：
Tissue_specificity:It is expressed (at the protein level) in fibroblasts, retinal pigment epithelial cells, and lymphoblasts.

Subunit：Homodimer (PubMed:16397295). Interacts with polynucleotide kinase (PNK), DNA polymerase-beta (POLB) and DNA ligase III (LIG3) (PubMed:19155274, PubMed:19336415). Interacts with APTX and APLF (PubMed:14755728, PubMed:15044383, PubMed:15380105, PubMed:17353262, PubMed:17507382). Interacts with APEX1; the interaction is induced by SIRT1 and increases with the acetylated form of APEX1 (PubMed:19934257). Interacts with (poly-ADP-ribosylated) PARP1 (PubMed:34811483)

Database

Entrez Gene: 7515 Human

SwissProt: P18887 Human

OMIM: 617633 Human

Research Field

Epigenetics and Nuclear Signaling

Synonyms

XRCC1; DNA repair protein XRCC1; X-ray repair cross-complementing protein 1

ドキュメンテーション

User Guide for Antibodies (1077 KB)