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Phospho-ATR (T1989) Antibody (YA6717)

(Synonyms: Ataxia telangiectasia and Rad3 related antibody; Ataxia telangiectasia and Rad3-related protein antibody; ATR antibody; ATR_HUMAN antibody; FCTCS antibody; FRAP Related Protein 1 antibody; FRAP-related protein 1 antibody; FRP1 antibody; MEC1 antibody; MEC1 mitosis entry checkpoint 1 homolog antibody; Ataxia telangiectasia and Rad3 related antibody; Ataxia telangiectasia and Rad3-related protein antibody; ATR antibody; ATR_HUMAN antibody; FCTCS antibody; FRAP Related Protein 1 antibody; FRAP-related protein 1 antibody; FRP1 antibody; MEC1 antibody; MEC1 mitosis entry checkpoint 1 homolog antibody; Protein kinase ATR antibody; RAC3 antibody; Rad3 related protein antibody; SCKL antibody; SCKL1 antibody; Serine/threonine protein kinase ATR antibody; Serine/threonine-protein kinase ATR antibody; )
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Phospho-ATR (T1989) Antibody (YA6717) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Phospho-ATR (T1989).

For research use only. We do not sell to patients.
  • Host:

    Rabbit

  • Isotype:

    IgG

  • Application:

    WB, ICC/IF

  • Reactivity :

    Human

  • Formulation:

    Supplied in PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

  • Conjugation:
    Non-conjugated
  • Phospho-ATR (T1989) Antibody (YA6717) Product Image
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To place orders, for customer services and technical support, please contact: MedChemExpress USA

Tel: 609-228-6898 E-mail: [email protected] [email protected]

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Applications

Application
WB Info
WB: Western Blot
ICC/IF Info
ICC/IF: Immunocytochemistry/
Immunofluorescence
Dilution Ratio 1:1000 1:200

Product Details

Description

Phospho-ATR (T1989) Antibody (YA6717) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Phospho-ATR (T1989).

  • Host Rabbit
  • Clonality Recombinant,Monoclonal
  • Species Reactivity
    Human
  • Calculated Molecular Weight Predicted band size: 301 kDa
Immunogen

Synthetic phosphopeptide corresponding to residues surrounding Thr1989 of human ATR.

Purification

affinity purified.

Conjugation

Non-conjugated

Modification

Phosphorylated

Isotype

IgG

RRID

AB_3719251

Product Properties

  • Appearance

    Solution

  • Formulation

    Supplied in PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

  • Concentration

    Batch-dependent, Please check the COA for the concentration of each lot. Check Lot Concentration

  • Storage & Stability

    Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

  • Shipping

    Shipping with blue ice.

Background

  • Function

    Ataxia telangiectasia mutated (ATM) encodes a serine/threonine protein kinase that coordinates cellular signaling after DNA double-strand breaks, oxidative stress, and cell-cycle checkpoint activation[1]. Mechanistically, ATM and ATR (ATM-Rad3-related) act as proximal DNA damage response kinases, but ATM is central to double-strand-break signaling, whereas ATR leads a parallel cascade activated by replication stress[2][3]. In disease contexts, ATM mutation causes ataxia-telangiectasia, a multisystem disorder involving neurodegeneration, immunodeficiency, radiosensitivity, cancer susceptibility, and genetic instability[4][5]. Compared with ATR, ATM deficiency creates experimental dependence on ATR in some cancer models, supporting ATR inhibition as a synthetic-lethal strategy in ATM-deficient prostate cancer and colorectal xenograft models[6][7]. For research applications, ATM inhibitors such as KU-55933 help interrogate ATM-dependent DNA damage signaling and have reduced HSV-1 replication and stromal keratitis severity in experimental corneal models[8].

  • Subcellular Localization

    Nucleus,Chromosome,Nucleus envelope

  • Expression


    Tissue_Specificity: Ubiquitous, with highest expression in testis|Isoform 2 is found in pancreas, placenta and liver but not in heart, testis and ovary

  • Isoforms & Post-Translational Modification

    Q13535 has three isomers: Q13535-1: 301367 Da (predicted); Q13535-2: 294219 Da (predicted); Q13535-3: 297479 Da (predicted).
    Phosphorylated (PubMed:21144835)

  • Subunit

    Forms a heterodimer with ATRIP, forming the ATR-ATRIP complex (PubMed:11721054, PubMed:12791985, PubMed:14729973, PubMed:15758953, PubMed:21777809)

  • SwissProt ID

    Q13535

  • Gene ID
    545 [NCBI]
  • Synonyms

    Ataxia telangiectasia and Rad3 related antibody; Ataxia telangiectasia and Rad3-related protein antibody; ATR antibody; ATR_HUMAN antibody; FCTCS antibody; FRAP Related Protein 1 antibody; FRAP-related protein 1 antibody; FRP1 antibody; MEC1 antibody; MEC1 mitosis entry checkpoint 1 homolog antibody; Ataxia telangiectasia and Rad3 related antibody; Ataxia telangiectasia and Rad3-related protein antibody; ATR antibody; ATR_HUMAN antibody; FCTCS antibody; FRAP Related Protein 1 antibody; FRAP-related protein 1 antibody; FRP1 antibody; MEC1 antibody; MEC1 mitosis entry checkpoint 1 homolog antibody; Protein kinase ATR antibody; RAC3 antibody; Rad3 related protein antibody; SCKL antibody; SCKL1 antibody; Serine/threonine protein kinase ATR antibody; Serine/threonine-protein kinase ATR antibody;

References

[1]. Amirifar P, et al. Ataxia-telangiectasia: A review of clinical features and molecular pathology. Pediatr Allergy Immunol. 2019 May;30(3):277-288. [Content Brief]

[2]. Mu JJ, et al. A proteomic analysis of ataxia telangiectasia-mutated (ATM)/ATM-Rad3-related (ATR) substrates identifies the ubiquitin-proteasome system as a regulator for DNA damage checkpoints. J Biol Chem. 2007 Jun 15;282(24):17330-4. [Content Brief]

[3]. Balmus G, et al. Disease severity in a mouse model of ataxia telangiectasia is modulated by the DNA damage checkpoint gene Hus1. Hum Mol Genet. 2012 Aug 1;21(15):3408-20. [Content Brief]

[4]. Meyn MS. Ataxia-telangiectasia, et al. Ataxia-telangiectasia, cancer and the pathobiology of the ATM gene. Clin Genet. 1999 May;55(5):289-304. [Content Brief]

[5]. Putti S, et al. ATM Kinase Dead: From Ataxia Telangiectasia Syndrome to Cancer. Cancers (Basel). 2021 Nov 1;13(21):5498. [Content Brief]

[6]. Gulliver C, et al. Ataxia-telangiectasia mutated and ataxia telangiectasia and Rad3-related kinases as therapeutic targets and stratification indicators for prostate cancer. Int J Biochem Cell Biol. 2022 Jun;147:106230. [Content Brief]

[7]. Shao J, et al. Design, Synthesis, and Biological Evaluation of Potent and Selective Inhibitors of Ataxia Telangiectasia Mutated and Rad3-Related (ATR) Kinase for the Efficient Treatment of Cancer. Molecules. 2023 Jun 2;28(11):4521. [Content Brief]

[8]. Alekseev O, et al. Inhibition of ataxia telangiectasia mutated (ATM) kinase suppresses herpes simplex virus type 1 (HSV-1) keratitis. Invest Ophthalmol Vis Sci. 2014 Feb 3;55(2):706-15. [Content Brief]

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Phospho-ATR (T1989) Antibody (YA6717) Related Classifications

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Measured by its ability to inhibit anti-CD3-induced proliferation of stimulated CTLL-2 mouse cytotoxic T cells. The ED50 this effect is 0.8023 μg/ml, corresponding to a specific activity is 1246.42 units/mg.

Assay Types
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  • Phospho-ATR (T1989) Antibody (YA6717) Product Image