1. Cell Cycle/DNA Damage
  2. Checkpoint Kinase (Chk)
    Wee1
  3. PD 407824

PD 407824 

Cat. No.: HY-18961 Purity: >98.0%
Handling Instructions

PD 407824 is a checkpoint kinase Chk1 and WEE1 inhibitor with IC50s of 47 and 97 nM, respectively. PD 407824 is a chemical BMP sensitizer and increases the sensitivity of cells to sub-threshold amounts of BMP4.

For research use only. We do not sell to patients.

PD 407824 Chemical Structure

PD 407824 Chemical Structure

CAS No. : 622864-54-4

Size Price Stock Quantity
10 mM * 1  mL in DMSO USD 138 In-stock
Estimated Time of Arrival: December 31
5 mg USD 125 In-stock
Estimated Time of Arrival: December 31
10 mg USD 230 In-stock
Estimated Time of Arrival: December 31
25 mg USD 440 In-stock
Estimated Time of Arrival: December 31
50 mg USD 750 In-stock
Estimated Time of Arrival: December 31
100 mg USD 1300 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Description

PD 407824 is a checkpoint kinase Chk1 and WEE1 inhibitor with IC50s of 47 and 97 nM, respectively. PD 407824 is a chemical BMP sensitizer and increases the sensitivity of cells to sub-threshold amounts of BMP4[1][2].

IC50 & Target[1]

Chk1

47 nM (IC50)

WEE1

97 nM (IC50)

In Vitro

PD 407824 is sufficient to block CHK1, leading to a significant down-regulation of p21, causing activation of CDK8/9, which in turn causes depletion of SMAD2/3[1].
PD 407824 is selective for Chk1 and WEE1 over PKC and Cdk4 with IC50s of 3.4 µM and 3.75 µM, respectively[3].

Molecular Weight

328.32

Formula

C₂₀H₁₂N₂O₃

CAS No.

622864-54-4

SMILES

O=C1NC(C2=C1C3=C(C=C2C4=CC=CC=C4)NC5=C3C=C(O)C=C5)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (761.45 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.0458 mL 15.2290 mL 30.4581 mL
5 mM 0.6092 mL 3.0458 mL 6.0916 mL
10 mM 0.3046 mL 1.5229 mL 3.0458 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (6.34 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (6.34 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

PD 407824PD407824PD-407824Checkpoint Kinase (Chk)Wee1Inhibitorinhibitorinhibit

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PD 407824
Cat. No.:
HY-18961
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