1. Cell Cycle/DNA Damage
  2. Checkpoint Kinase (Chk)
    Wee1
  3. PD 407824

PD 407824 

Cat. No.: HY-18961
Handling Instructions

PD 407824 is a checkpoint kinase Chk1 and WEE1 inhibitor with IC50s of 47 and 97 nM, respectively. PD 407824 is a chemical BMP sensitizer and increases the sensitivity of cells to sub-threshold amounts of BMP4.

For research use only. We do not sell to patients.

PD 407824 Chemical Structure

PD 407824 Chemical Structure

CAS No. : 622864-54-4

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Description

PD 407824 is a checkpoint kinase Chk1 and WEE1 inhibitor with IC50s of 47 and 97 nM, respectively. PD 407824 is a chemical BMP sensitizer and increases the sensitivity of cells to sub-threshold amounts of BMP4[1][2].

IC50 & Target[1]

Chk1

47 nM (IC50)

WEE1

97 nM (IC50)

In Vitro

PD 407824 is sufficient to block CHK1, leading to a significant down-regulation of p21, causing activation of CDK8/9, which in turn causes depletion of SMAD2/3[1].
PD 407824 is selective for Chk1 and WEE1 over PKC and Cdk4 with IC50s of 3.4 µM and 3.75 µM, respectively[3].

Molecular Weight

328.32

Formula

C₂₀H₁₂N₂O₃

CAS No.

622864-54-4

SMILES

O=C1NC(C2=C1C3=C(C=C2C4=CC=CC=C4)NC5=C3C=C(O)C=C5)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

PD 407824PD407824PD-407824Checkpoint Kinase (Chk)Wee1Inhibitorinhibitorinhibit

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