Checkpoint Kinase (Chk) Inhibitors

Chk1

Chk2

Checkpoint Kinase (Chk) Inhibitors & Activators

Product Name	Chk1	Chk2	Purity
Prexasertib	Chk1, IC₅₀: <1 nM Chk1, Ki: 0.9 nM	Chk2, IC₅₀: 8 nM	98.74%
AZD-7762	Chk1, IC₅₀: 5 nM	Chk2, IC₅₀: 5 nM	99.94%
Rabusertib	Chk1, IC₅₀: 7 nM	Chk2, IC₅₀: 12000 nM	99.99%
SCH900776	Chk1, IC₅₀: 3 nM	Chk2, IC₅₀: 1500 nM	99.97%
BML-277		Chk2, IC₅₀: 15 nM	98.47%
CCT245737	Chk1, IC₅₀: 1.3 nM	Chk2, IC₅₀: 2440 nM	99.24%
Prexasertib dihydrochloride	Chk1, IC₅₀: <1 nM Chk1, Ki: 0.9 nM	Chk2, IC₅₀: 8 nM	99.41%
CHIR-124	Chk1, IC₅₀: 0.3 nM	Chk2, IC₅₀: 697.4 nM	98.57%
CCT241533 hydrochloride	Chk1, IC₅₀: 245 nM	Chk2, IC₅₀: 3 nM Chk2, Ki: 1.16 nM	99.87%
CCT244747	Chk1, IC₅₀: 7.7 nM		99.17%
PF 477736	Chk1, Ki: 0.49 nM	Chk2, Ki: 47 nM	99.21%
Prexasertib dimesylate	Chk1, Ki: 0.9 nM Chk1, IC₅₀: <1 nM	Chk2, IC₅₀: 8 nM	99.04%
MRT00033659	Chk1, IC₅₀: 0.23 μM		99.77%
SB-218078	Chk1, IC₅₀: 15 nM		≥98.0%
GDC-0575 dihydrochloride	Chk1, IC₅₀: 1.2 nM		99.49%
GNE-900	Chk1, IC₅₀: 0.0011 μM	Chk2, IC₅₀: 1.5 μM	99.21%
ANI-7		Chk2	98.13%
CHK1-IN-3	Chk1, IC₅₀: 0.4 nM		99.79%
CCT241533	Chk1, IC₅₀: 245 nM	Chk2, IC₅₀: 3 nM Chk2, Ki: 1.16 nM
Prexasertib Mesylate Hydrate	Chk1, Ki: 0.9 nM Chk1, IC₅₀: <1 nM	Chk2, IC₅₀: 8 nM
Prexasertib mesylate	Chk1, Ki: 0.9 nM Chk1, IC₅₀: <1 nM	Chk2, IC₅₀: 8 nM
CHK1-IN-4	Chk1
CHK1-IN-2	Chk1, IC₅₀: 6 nM
Chk1-IN-5	Chk1
Chk2-IN-1	Chk1, IC₅₀: 220.4 nM	Chk2, IC₅₀: 13.5 nM
GDC0575 hydrochloride	Chk1, IC₅₀: 1.2 nM
CCT241533 dihydrochloride	Chk1, IC₅₀: 245 nM	Chk2, IC₅₀: 3 nM Chk2, Ki: 1.16 nM
CHK1-IN-9	Chk1, IC₅₀: 0.55 nM
Chk1-IN-6	Chk1
PV-1019		Chk2, IC₅₀: 24 nM
Multi-kinase-IN-6	Chk1, IC₅₀: 0.15 μM
CHK-IN-1	Chk1	Chk2

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