2. Cell Cycle/DNA Damage Apoptosis
  3. DNA/RNA Synthesis Apoptosis
  4. Oxaliplatin

Oxaliplatin 

Cat. No.: HY-17371 Purity: ≥98.0%
COA Handling Instructions

Oxaliplatine est un inhibiteur de la synthèse d'ADN. Oxaliplatine provoque des dommages de réticulation de l'ADN, empêche la réplication et la transcription de l'ADN et provoque la mort cellulaire. Oxaliplatine inhibe les lignées cellulaires de mélanome humain C32 et G361 en fonction du temps avec des valeurs IC50 de 0,98 μM et 0,14 μM, respectivement. Oxaliplatine induit l'autophagie cellulaire.

Oxaliplatin is a DNA synthesis inhibitor. Oxaliplatin causes DNA crosslinking damage, prevents DNA replication and transcription and induces apoptosis. Oxaliplatin can be used for cancer research.

For research use only. We do not sell to patients.

Oxaliplatin Chemical Structure

Oxaliplatin Chemical Structure

CAS No. : 61825-94-3

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Customer Review

Based on 82 publication(s) in Google Scholar

Other Forms of Oxaliplatin:

Oxaliplatin Related Antibodies

Top Publications Citing Use of Products

81 Publications Citing Use of MCE Oxaliplatin

IF

    Oxaliplatin purchased from MCE. Usage Cited in: Nat Med. 2019 Sep;25(9):1428-1441.  [Abstract]

    Quantification of CD3+IFN-γ+ T cells in lung lobes taken from urethane-induced primary lung cancer models (n = 5 mice for SD group, n = 6 mice for all the other groups). Three coronal sections containing five pulmonary lobes from each mouse near the maximal diameters are quantified. Each dot represents one view field. A representative result from two independent experiments is shown.

    • Biological Activity

    • Purity & Documentation

    • References

    • Customer Review

    Description

    Oxaliplatin is a DNA synthesis inhibitor. Oxaliplatin causes DNA crosslinking damage, prevents DNA replication and transcription and induces apoptosis. Oxaliplatin can be used for cancer research[1][2][3].

    IC50 & Target

    IC50: DNA synthesis[1]
    In Vitro

    Oxaliplatin (24-72 hours; 2-128 μM; HCC, HCCLM3 and Hep3B cells) inhibits cell growth and induces apoptosis[1].
    ? Oxaliplatin (10 μM; 15-240 mins; CEM cells ) induces primary and secondary DNA lesions, including DNA cross-links (ISC) and DNA-protein cross-links (DPC)[2].
    ? Oxaliplatin (0.01 to 100 μM; 24 hours) potently inhibits bladder carcinoma cell lines RT4 and TCCSUP, ovarian carcinoma cell line A2780, colon carcinoma cell line HT-29, glioblastoma cell lines U-373MG and U-87MG, and melanoma cell lines SK-MEL-2 and HT-144 with IC50 of 11 μM, 15 μM, 0.17 μM, 0.97 μM, 2.95 μM, 17.6 μM, 30.9 μM and 7.85 μM, respectively[3].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Oxaliplatin Related Antibodies

    Cell Viability Assay[1]

    Cell Line: HCC, HCCLM3 and Hep3B cells
    Concentration: 24, 48 and 72 hours
    Incubation Time: 2, 4, 8, 16, 32, 64 and 128 μM
    Result: Decreased cell viability in a dose- and time-dependent manner.

    Cell Cycle Analysis[1]

    Cell Line: HCCLM3 and Hep3B cells
    Concentration: 10 μM
    Incubation Time: 24 hours
    Result: Increased the percentage of apoptotic cells (17.70% for HCCLM3 cells; 21.19% for Hep3B cells).

    Cell Cycle Analysis[1]

    Cell Line: HCCLM3 cells
    Concentration: 10 μM
    Incubation Time: 48 hours
    Result: Down-regulated the expression of Bcl-2 and Bcl-xL, and increased the expression of Bax.
    In Vivo

    Oxaliplatin (5-10 mg/kg; i.p.; for 32 days; nude mice) inhibits tumor growth[1].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Nude mice[1]
    Dosage: 5 and 10 mg/kg
    Administration: Intraperitoneal injection; for 32 days
    Result: Reduced tumor volume in HCCLM3 tumor xenografts.
    Clinical Trial
    Molecular Weight

    397.29

    Appearance

    Solid

    Formula

    C8H14N2O4Pt
    CAS No.
    SMILES

    O=C(O1)C(O[Pt]21[NH2][C@@H]3CCCC[C@H]3[NH2]2)=O
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    4°C, protect from light

    *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

    Solvent & Solubility
    In Vitro: 

    H2O : 2.17 mg/mL (5.46 mM; ultrasonic and warming and heat to 60°C; DMSO can inactivate Oxaliplatin's activity)

    DMF : 1.67 mg/mL (4.20 mM; Need ultrasonic; DMSO can inactivate Oxaliplatin's activity)

    Ethanol : < 1 mg/mL (insoluble; DMSO can inactivate Oxaliplatin's activity)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 2.5171 mL 12.5853 mL 25.1705 mL
    5 mM 0.5034 mL 2.5171 mL 5.0341 mL
    10 mM --- --- ---
    *Please refer to the solubility information to select the appropriate solvent.
    In Vivo:
    • 1.

      Add each solvent one by one:  5% w/v Glucose Solution

      Solubility: 3.33 mg/mL (8.38 mM); Clear solution; Need ultrasonic

    • 2.

      Add each solvent one by one:  PBS

      Solubility: 1.92 mg/mL (4.83 mM); Clear solution; Need ultrasonic and warming and heat to 60°C

    *All of the co-solvents are available by MCE.
    Purity & Documentation

    Purity: 99.57%

    COA (253 KB) HNMR (215 KB) LCMS (348 KB) Elemental Analysis Report (110 KB)

    Handling Instructions (2659 KB)
    References
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    Oxaliplatin Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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    × = ×
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    Keywords:

    Oxaliplatin61825-94-3DNA/RNA SynthesisApoptosisapoptosisDNA cross-linksDNA-protein cross-linksanticancerInhibitorinhibitorinhibit

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