Hypoxia-induced acidic microenvironment alters cellular pharmacokinetics of gastric cancer in a Mongolian population

  • J Biomed Res. 2026 Apr 25:1-18. doi: 10.7555/JBR.39.20250238.
Jiawen Cheng  1 ,  Zhouyue Wu  2 ,  Mengran Wang  3  4 ,  Liguo Wang  3  4 ,  Chenchen Jiang  2 ,  Xiang Chen  2 ,  Minghui Zhang  4 ,  Le Xia  2  5 ,  Tingting Yang  2  5 ,  Lulu Zhang  2 ,  Xuezhi Wang  3  4 ,  Yixuan Zhang  2  6
Affiliations
  • 1. Department of Physiology, School of Basic Medical Sciences, Nanjing Medical University, Nanjing, 211166, China.
  • 2. Medical Basic Research Innovation Center for Cardiovascular and Cerebrovascular Diseases, Ministry of Education, China; International Joint Laboratory for Drug Target of Critical Illnesses, School of Pharmacy, Nanjing Medical University, Nanjing 211166, China.
  • 3. Affiliated Chifeng Clinical College of Inner Mongolia Medical University, Chifeng 024000, China.
  • 4. Department of Tumor Surgery, Chifeng Municipal Hospital, Chifeng 024000, China.
  • 5. School of Tianyuan Honors, Nanjing Medical University, Nanjing, 211166, China.
  • 6. The affiliated Huaian No.1 People's Hospital of Nanjing Medical University, Northern Jiangsu Institute of Clinical Medicine, Huaian 223300, China.
PMID: 41953981 DOI: 10.7555/JBR.39.20250238
Abstract

This study aims to comprehensively analyze the transcriptome characteristics of Mongolian gastric Cancer (GC) patients to elucidate the critical molecular events underlying treatment response in this ethnic population. The objective is to establish connections between these molecular events and the cellular pharmacokinetics of chemotherapy drugs. Our investigation revealed increased activation of the hypoxia pathway in GC tumor tissues from Mongolian individuals, which was significantly associated with adverse prognosis. Through analysis of hypoxia-induced changes in cellular pharmacokinetics, we identified three chemotherapy drugs-paclitaxel, oxaliplatin, and tegafur-gimeracil-oteracil potassium capsules (TGO)-that exhibit distinct transport and metabolic characteristics in GC tumor cells of Mongolian nationality. These findings provide valuable insights for clinical practice, particularly in refining treatment strategies and advancing personalized medicine for Mongolian GC patients.

Keywords
Cellular Pharmacokinetics; Gastric Cancer; Mongolian population; Tumor microenvironment.
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