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Ro-3306

74 Cited Publications
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Based on 74 publication(s) in Google Scholar

Ro-3306 is a potent and selective inhibitor of CDK1, with Kis of 20 nM, 35 nM and 340 nM for CDK1, CDK1/cyclin B1 and CDK2/cyclin E, respectively.

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  • Pureté: 99.57%
  • CAS No.: 872573-93-8
  • Formule: C18H13N3OS2
  • Masse moléculaire:351.45
  • Stockage:
    Powder   -20°C, 3 years , 4°C, 2 years ; In solvent   -80°C, 1 year , -20°C, 6 months
  • Ro-3306 Chemical Structure
    Ro-3306 Chemical Structure
  • Experimental Validation Results for Ro-3306
  • Experimental Validation Results for Ro-3306
  • Experimental Validation Results for Ro-3306
  • Experimental Validation Results for Ro-3306
  • Experimental Validation Results for Ro-3306
  • Experimental Validation Results for Ro-3306
  • Experimental Validation Results for Ro-3306
  • Experimental Validation Results for Ro-3306
CAS No.: 872573-93-8
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  • Ro-3306 Chemical Structure
    Ro-3306 Chemical Structure
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    Ro-3306 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2024 Nov 12;15(1):9529. [Abstract]

    Customer Validation
     Percentage of WT, KO1, and KO2 cells in G1 phase at 0, 0.5, 1, 1.5, 2, and 2.5-hour release after RO-3306 (9 μM) drug treatment for 20 hours; means + s.d. (n = 3), at indicated times, unpaired two-tailed t-test

  • 1/16

    Ro-3306 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2023 May 26;14(1):3050. [Abstract]

    Customer Validation
     Analyzes of TRABID mRNA and protein levels in HeLa cells treated with 10 μM lovastatin, 2 μg/ml aphidicolin, 10 μM RO-3306, or 3 μM nocodazole for 18 h. Data are mean ± SD, n = 3 independent experiments. P values are determined by one-way ANOVA with Tukey’s post hoc test.

  • 1/16

    Ro-3306 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2023 May 26;14(1):3050. [Abstract]

    Customer Validation
     HeLa cells transiently expressing V5-TRABID were synchronized at G2 by treatment with 10 μM RO-3306 for 16 h and then released to proceed the cell cycle for 40 min before monitoring the PLA signal with indicated antibodies.

  • 1/16

    Ro-3306 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2023 May 26;14(1):3050. [Abstract]

    Customer Validation
     Westernblot analysis of TRABID mRNA and protein levels in HeLa cells treated with 10 μM Lovastatin, 2 μg/ml Aphidicolin, 10 μM RO-3306, or 3 μM Nocodazole for 18 h.

  • 1/16

    Ro-3306 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2023 May 26;14(1):3050. [Abstract]

    Customer Validation
     RT-qPCR analysis of TRABID mRNA and protein levels in HeLa cells treated with 10 μM Lovastatin, 2 μg/ml Aphidicolin, 10 μM RO-3306, or 3 μM Nocodazole for 18 h.

  • 1/16

    Ro-3306 purchased from MedChemExpress. Usage Cited in: Cancer Res. 2021 Aug 1;81(15):4079-4093. [Abstract]

    Customer Validation
     Telomere qPCR of NEIL1 digestion in HEP3B cells transfected with NEIL3 siRNA s2, s4, or nontargeting control (siCtrl) for 72 hours. After transfection, cells were synchronized in G1 with 2 mmol/L thymidine, followed by synchronization in G2 with RO-3306 (10 μmol/L, 16 h). Cells were released into mitosis and treated with 2.5 mmol/L KBrO3 for 30 minutes, followed by recovery for 60 minutes.

  • 1/16

    Ro-3306 purchased from MedChemExpress. Usage Cited in: Cancer Res. 2021 Aug 1;81(15):4079-4093. [Abstract]

    Customer Validation
     Images of NEIL3 foci (red) and telomere (TTAGGG; green) colocalization by anti-NEIL3 IF and telo-FISH in HEP3B cells. Cells were treated with DMSO, 24-hour vincristine (VCR; 20 nmol/L), 24-hour vincristine (20 nmol/L) + 24-hour Reversine (REV; 0.5 μmol/L) or 24-hour RO-3306 (10 μmol/L).

  • 1/16

    Ro-3306 purchased from MedChemExpress. Usage Cited in: Oncogene. 2018 May;37(19):2601-2614. [Abstract]

    Customer Validation
     HEK-293T cells are treated with the ERK1/2 inhibitor SCH772984 (0.5 µM) and/or the CDK1 inhibitor RO-3306 (9 μM) during the last 18 h of transfection. Cells are lysed after 24 h and western blot is performed with the indicated antibodies. HSP90 is used as a loading control.

  • Ro-3306