2. Oligonucleotides
  3. mRNA
  4. Gene Editing

Gene Editing

Gene Editing (8):

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-185051
    OTX-2002
    OTX-2002 is an mRNA encoding two bifunctional fusion proteins (ZFBD-MQ1 and ZFBD-KRAB). OTX-2002 targets regulatory elements located within the MYC protection gene domain (IGD) and induces the methylation of DNA and histone, leading to the downregulation of MYC expression.
    OTX-2002
  • HY-185560
    Ziclumeran 2305431-29-0
    Ziclumeran is a Cas9 mRNA and a component of Nexiguran Ziclumeran.
    Ziclumeran
  • HY-174794
    Cas9-T2A-GFP mRNA
    The Cas9-T2A-GFP mRNA encodes a Cas9 nuclease gene with two nuclear localization signals (NLS) and a green fluorescent protein (GFP), which could be used in genome engineering experiments.
    Cas9-T2A-GFP mRNA
  • HY-174793
    Cas9-T2A-GFP mRNA (N1-Methylpseudo-UTP)
    The Cas9-T2A-GFP mRNA encodes a Cas9 nuclease gene with two nuclear localization signals (NLS) and a green fluorescent protein (GFP), which could be used in genome engineering experiments. The incorporation of N1-Methylpseudo-UTP can reduce the immunogenicity of the resulting mRNA.
    Cas9-T2A-GFP mRNA (N1-Methylpseudo-UTP)
  • HY-174792
    Cre-T2A-GFP mRNA
    The Cre-T2A-GFP mRNA is a capped and polyadenylated messenger RNA encoding a Cre recombinase with a nuclear localization sequence (NLS) and a green fluorescent protein (GFP).
    Cre-T2A-GFP mRNA
  • HY-174791
    Cre-T2A-GFP mRNA (N1-Methylpseudo-UTP)
    The Cre-T2A-GFP mRNA is a capped and polyadenylated messenger RNA encoding a Cre recombinase with a nuclear localization sequence (NLS) and a green fluorescent protein (GFP). The incorporation of N1-Methylpseudo-UTP can reduce the immunogenicity of the resulting mRNA.
    Cre-T2A-GFP mRNA (N1-Methylpseudo-UTP)
  • HY-174500
    eSpCas9 mRNA
    The eSpCas9 mRNA expresses enhanced-specificity SpCas9 protein, with sequence originally from Slaymaker et al Science. 2015 Dec 1.
    eSpCas9 mRNA
  • HY-174499
    Cas9 Nickase D10A mRNA (5moU)
    Cas9 Nickase D10A mRNA expresses a version of the Streptococcus pyogenes SF370 Cas9 protein (CRISPR Associated Protein 9) that contains a D10A amino acid substitution. This mRNA also contains a C-terminal nuclear localization signal followed by a HA tag.Cas9 functions as part of the CRISPR (clustered regularly interspaced short palindromic repeats) genome editing system. In the CRISPR system, an RNA guide sequence targets the site of interest and the Cas9 protein is employed to perform the DNA cleavage. While wild-type Cas9 creates a double-stranded break at the target site, Cas9 nickase creates a single-stranded break. This favors homology-directed repair and decreases the occurrence of non-homologous end joining.
    Cas9 Nickase D10A mRNA (5moU)