DDR1 Protein, Mouse (HEK293, Fc)

DDR1 Protein, a fibrillar collagen receptor, orchestrates critical cellular processes, including matrix remodeling, migration, differentiation, survival, and proliferation. Upon collagen binding, DDR1 activates a signaling cascade involving SRC and MAP kinases, contributing to matrix remodeling through MMP up-regulation, facilitating cell migration, wound healing, and tumor invasion. DDR1 also aids arterial wound healing, phosphorylates PTPN11, and is vital for blastocyst implantation, mammary gland differentiation, lactation, and ear morphology maintenance. Its multifunctional role underscores DDR1's significance in governing diverse physiological processes. DDR1 Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived DDR1 protein, expressed by HEK293, with C-hFc labeled tag. The total length of DDR1 Protein, Mouse (HEK293, Fc) is 414 a.a., with molecular weight of 80-90 kDa.

DDR1 protein, a tyrosine kinase functioning as a cell surface receptor for fibrillar collagen, orchestrates diverse cellular processes critical for tissue homeostasis. It regulates cell attachment to the extracellular matrix, influencing matrix remodeling, cell migration, differentiation, survival, and proliferation. Upon collagen binding, DDR1 initiates a signaling cascade involving SRC and leading to MAP kinase activation. This intricate network contributes to extracellular matrix remodeling through the up-regulation of matrix metalloproteinases MMP2, MMP7, and MMP9, facilitating cell migration and wound healing, as well as promoting tumor cell invasion. DDR1's impact extends to arterial wound healing by promoting smooth muscle cell migration. Furthermore, it phosphorylates PTPN11 and is indispensable for normal blastocyst implantation during pregnancy, mammary gland differentiation, lactation, and maintenance of normal ear morphology and hearing. The multifunctional role of DDR1 underscores its significance in governing diverse physiological processes.

Mouse

HEK293

C-hFc

Q03146-2 (M1-T414)

12305  [NCBI]

80-90 kDa

Greater than 95% as determined by reducing SDS-PAGE

<1 EU/μg, determined by LAL method.